PMID: 8610531Jan 1, 1995Paper

Bioanalytical methods for iodixanol and their application to studies on metabolism and protein binding

Acta Radiologica. Supplementum
P B JacobsenT Skotland

Abstract

The iodine-specific detection techniques X-ray fluorescence spectrometry, neutron activation analysis and radiochemical detections of (125)I-labelled substance are well suited for quantification of iodixanol in biological samples. The limit of detection is 60 microgram iodixanol/ml for X-ray fluorecence analysis and 1 to 10 microgram iodixanol/ml for neutron activation analysis. Reversed-phase high-performance liquid chromatography (HPLC) has been employed when selective determination of iodixanol was needed for identificational purposes or when quantification of very small amounts of iodixanol was essential. An optimized HPLC method for quantification of iodixanol in rat serum and urine is presented. The limit of detection for this method is 0.20 microgram iodixanol/ml for rat serum and 3.0 microgram iodixanol/ml for rat urine. When samples were analyzed by HPLC and thin layer chromatography, no metabolites of iodixanol were observed in rat, monkey or human urine, or in rat kidney and bile. Studies with equilibrium dialysis and HPLC determination of iodixanol showed no protein binding of the contrast agent in human plasma; the 95% confidence interval for the result was 0.0+/-2.1%.

References

Feb 1, 1992·Investigative Radiology·M G SvalandP A Hals
May 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·S E BäckP Nilsson-Ehle
Mar 1, 1983·Investigative Radiology·B OlssonE Andrew

❮ Previous
Next ❯

Citations

Jul 8, 2014·The Journal of Veterinary Medical Science·Ryosuke IwamaHiroshi Satoh
Aug 30, 2014·Physiological Reports·Yui SasakiKazuhisa Furuhama
Apr 14, 2015·The Journal of Veterinary Medical Science·Ryosuke IwamaKazuhisa Furuhama
Aug 27, 2015·American Journal of Veterinary Research·Yui SasakiKazuhisa Furuhama
May 23, 2015·Journal of Applied Toxicology : JAT·Hiroshi SatohKazuhisa Furuhama
Oct 8, 2013·Rapid Communications in Mass Spectrometry : RCM·Erlend Hvattum, Hanno Priebe
Jul 23, 2011·The Journal of Veterinary Medical Science·Kyoko ImaiKazuhisa Furuhama
Aug 29, 2012·American Journal of Veterinary Research·Rieko KatayamaKazuhisa Furuhama
Jun 6, 2013·Journal of Feline Medicine and Surgery·Masaaki KatayamaKazuhisa Furuhama
Sep 5, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Isao MurayamaKazuhisa Furuhama
Nov 15, 2011·The Journal of Veterinary Medical Science·Danil KimShuichi Ohashi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.