Bioartificial liver support systems for acute liver failure: A systematic review and meta-analysis of the clinical and preclinical literature

World Journal of Gastroenterology : WJG
Yu-Ting HeJi Bao

Abstract

Acute liver failure (ALF) has a high mortality varying from 80% to 85% with rapid progress in multi-organ system failure. Bioartificial liver (BAL) support systems have the potential to provide temporary support to bridge patients with ALF to liver transplantation or spontaneous recovery. In the past decades, several BAL support systems have been conducted in clinical trials. More recently, concerns have been raised on the renovation of high-quality cell sources and configuration of BAL support systems to provide more benefits to ALF models in preclinical experiments. To investigate the characteristics of studies about BAL support systems for ALF, and to evaluate their effects on mortality. Eligible clinical trials and preclinical experiments on large animals were identified on Cochrane Library, PubMed, and EMbase up to March 6, 2019. Two reviewers independently extracted the necessary information, including key BAL indicators, survival and indicating outcomes, and adverse events during treatment. Descriptive analysis was used to identify the characteristics of the included studies, and a meta-analysis including only randomized controlled trial (RCT) studies was done to calculate the overall effect of BAL on mortality among hum...Continue Reading

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Citations

May 21, 2020·Transplantation·Joshua HeflerA M James Shapiro
Feb 26, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·W Huber, A P Ruiz de Garibay
Jan 5, 2021·Advanced Functional Materials·Dantong HuangKam W Leong
Jul 31, 2021·World Journal of Gastroenterology : WJG·Kapil GuptaVinod K Rustgi

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Software Mentioned

RevMan
Review Manager
SPSS
HBAL
HepatAssist
HBALSS
MELS

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