Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam

Journal of Ethnopharmacology
Zeliha AkdemirHikmet Keles

Abstract

The leaves, flowers and whole aerial parts of Verbascum L. species have been used to treat respiratory problems, haemorrhoids and other types of inflammatory conditions in traditional Turkish medicine. In order to evaluate this traditional information, the anti-inflammatory, antinociceptive and wound healing activities of Verbascum mucronatum Lam. which is used as haemostatic in Turkish folk medicine were investigated. In vivo inhibitory effect of the extracts on the carrageenan-induced hind paw edema model in mice was studied for the assessment of anti-inflammatory activity. Moreover, the wound healing potential of the plant were evaluated by using in vivo wound healing experimental models, i.e. incision and excision models on mice and rats, were comparatively assessed with a reference ointment Madecassol(®). Skin samples were also evaluated histopathologically. The results of these experimental studies exhibited that Verbascum mucronatum displays anti-inflammatory, antinociceptive and wound healing activities. Through bioassay-guided fractionation and isolation procedures four iridoid glucosides, ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two saponins, ilwensisaponin A (5) and C (6) and a phenylethanoid glyco...Continue Reading

References

Apr 12, 2001·Journal of Ethnopharmacology·E SezikT Tanaka
Aug 8, 2002·Phytotherapy Research : PTR·Lonchin SugunaGowri Chandrakasan
Sep 21, 2002·Journal of Ethnopharmacology·Arzu Ucar Turker, N D Camper
Oct 14, 2005·Phytotherapy Research : PTR·Arzu Ucar Turker, Ekrem Gurel
Jun 13, 2006·Journal of Ethnopharmacology·Farzana Sadaf Navaid-ul-Zafar
Jun 30, 2006·Journal of Ethnopharmacology·Santram LodhiA K Singhai
Nov 23, 2006·Journal of Ethnopharmacology·Erdem Yesilada, Esra Küpeli
Jul 22, 2008·Journal of Ethnopharmacology·Nadine BackhouseHugo Miranda

❮ Previous
Next ❯

Citations

Dec 10, 2013·Journal of Pharmaceutical and Biomedical Analysis·Yujuan LiYulin Deng
Aug 10, 2013·The Journal of Pharmacy and Pharmacology·Abdel Nasser SingabMichael Wink
Feb 24, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Arie BudovskyShimon Ben-Shabat
Jul 23, 2014·Biotechnology Advances·Kalina AlipievaMilen I Georgiev
Aug 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhenzhen Xue, Bin Yang
Mar 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gulay OzkanEsra Capanoglu
Jun 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xu-Guang ZhangJun-Qing Zhang
Feb 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weronika AdachAdam Cieslak
Mar 11, 2021·Journal of Complementary & Integrative Medicine·Sandesh R Wayal, Shailendra S Gurav
Jun 10, 2021·BMC Complementary Medicine and Therapies·Sahar Taleb, Maryam Saeedi
Jun 29, 2021·Journal of Agricultural and Food Chemistry·Morgane CarraraDelphine Margout

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.