PMID: 12778181Aug 1, 1980Paper

Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CAS No. 57653-85-7,CAS No. 19408-74-3)

National Toxicology Program Technical Report Series
National Toxicology Program

Abstract

Hexachlorodibenzo-p-dioxins (HCDD) are formed during the manufacture of certain chlorophenols. They have been found in trichlorophenol, tetrachlorophenol, and pentachlorophenol and in the chlorophenol-derived herbicides, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). From 1967 to 1970, the concentration of HCDD in commercial pentachlorophenol ranged from 0.03 to 38 ppm. Since then, HCDD levels in pentachlorophenol have been less than 1 ppm. A bioassay of a mixture of 1,2,3,6,7,8- and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxin (HCDD) for possible carcinogenicity was conducted by administering the test material by gavage to Osborne-Mendel rats and B6C3F1 mice for 104 weeks. Fifty rats and 50 mice of each sex were administered HCDD suspended in a vehicle of 9:1 corn oil-acetate 2 days per week for 104 weeks at doses of 1.25, 2.5, or 5 &mgr;g/kg/wk for rats and male mice and 2.5, 5, or 10 &mgr;g/kg/wk for female mice. Seventy-five rats and 75 mice of each sex served as vehicle controls. In addition, one untreated control group containing 25 rats and 25 mice of each sex was present in the HCDD treatment room, and one untreated control group containing 25 rats and 25 mice of each sex was present i...Continue Reading

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