Bioassays guided isolation of compounds from Chaetomium globosum

Journal de mycologie médicale
N E AwadA M M El-Feky

Abstract

The aim of the present study was to evaluate different biological activities of the fungus Chaetomium globosum (family Chaetomiaceae). The evaluation was done through testing its antimicrobial, antioxidant and anticancer effects. C. globosum was isolated from the Cucumber soil (rhizosphere) and caused inhibition of the mycelial growth of Fusarium solani, Rhizoctonia solani and Sclerotium rolfsii in the biculture test. Petroleum ether and ethyl acetate extracts of the liquid culture of C. globosum showed potent in vitro antioxidant activity. C. globosum proved potent antibacterial activity against Bacillus subtilis, Escherichia coli and Pseudomonas fluorescens. It also recorded significant antifungal activity against Candida albicans, F. solani, Fusarium oxysporum, R. solani and Pythium ultimum. It exerted cytotoxic effect on human hepatocellular carcinoma cell line (HepG2). Unsaponifiable and saponifiable matters of the petroleum ether extract showed the presence of hydrocarbons, sterols and fatty acids. The ethyl acetate extract showed the presence of prenisatin, chrysophanol, chrysazin, chaetoviridin A and B. The isolated secondary metabolites proved significant antioxidant and antimicrobial activity on B. subtilis, E. coli a...Continue Reading

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Citations

Oct 21, 2015·Frontiers in Plant Science·Marcelo FridlenderHinanit Koltai
Nov 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei YanYong-Hao Ye
Nov 18, 2020·Toxins·Marco Masi, Antonio Evidente
Oct 16, 2021·Molecular Plant-microbe Interactions : MPMI

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