PMID: 2488614Jan 1, 1989Paper

Bioassays in whole animals

Journal of Pharmaceutical and Biomedical Analysis
J van Noordwijk

Abstract

The basis for whole animal bioassays as practised today was laid down by Paul Ehrlich in 1894. He introduced the concepts of a stable standard preparation and of the unit of activity as the activity of a defined mass of that standard preparation in the assay performed. Such assays have often provided a way of quantifying newly discovered active principles of biological origin, so that they could be applied in clinical medicine. Whole animal bioassays can be applied not only for the quantitative analysis of a biological product (analytical assays), but also for the comparison of different products intended for the same clinical indication (comparative or research assays). As such they have been the model for controlled clinical trial. For some products many different types of bioassay have been developed. They may produce heterogeneous results when more than one active principle is involved, and these are present in standard preparation and in the unknown preparation in different relative concentrations. In addition the precision of different assay methods for the same substance may vary markedly. An important source of variation in whole animal bioassays is the influence of some environmental factors on the individual animals d...Continue Reading

References

Jun 1, 1950·The Journal of Hygiene·J O Irwin

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Citations

Jun 20, 2020·Genome Génome / Conseil National De Recherches Canada·Cassandra Millet-BoureimaChiara Gamberi

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