Bioavailability and nervous tissue distribution of pyrethroid insecticide cyfluthrin in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
José-Luis RodríguezMaría-Aránzazu Martínez

Abstract

Toxicokinetics of cyfluthrin after single oral [20 mg/kg body weight (bw)] and intravenous (IV) (3 mg/kg bw) doses were studied in rats. Serial blood samples were obtained after oral and IV administration. Brain tissue samples were also collected after oral administration. Cyfluthrin concentrations in plasma and brain tissues (hypothalamus, striatum, hippocampus and frontal cortex) were quantified using liquid chromatography tandem mass spectrometry (LC/MS). Cyfluthrin disposition was best described by the use of a two-compartment open model. When given orally, plasma kinetics showed an extensive oral absorption of cyfluthrin and a slow elimination. The area under the concentration-time curve [AUC (0-24h)] and maximal plasma concentration (Cmax) were 6.11 ± 1.06 mg h/L and 0.385 ± 0.051 μg/mL, respectively; β phase elimination half-life (T1/2β) was (17.15 ± 1.67 h). Oral bioavailability was found to be 71.60 ± 12.36%. After oral administration, cyfluthrin was widely distributed to brain tissues. AUC (0-24h) was significant higher in all tested brain tissues than in plasma. The largest discrepancy was found for hypothalamus. AUC (0-24h), Cmax and T1/2β in hypothalamus were 19.36 ± 2.56 mg h/L, 1.21 ± 0.11 μg/g and 22.73 ± 1.60 h...Continue Reading

Citations

Dec 16, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yasmina M Abd-ElhakimMostafa A Shalaby
Aug 28, 2020·The Science of the Total Environment·María Teresa Muñoz-QuezadaVerónica Iglesias

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