Bioavailability and pharmacokinetics of sulphadiazine, N4-acetylsulphadiazine and trimethoprim following intravenous and intramuscular administration of a sulphadiazine/trimethoprim combination in sheep

Veterinary Research Communications
G C BatziasM Koutsoviti-Papadopoulou

Abstract

The combination of sulphadiazine and trimethoprim is extensively used in farm animal species; however, there are no data concerning its pharmacokinetics after intramuscular administration in sheep. Twelve rams of the Chios breed were used to study the disposition of sulphadiazine, its metabolite N4-acetylsulphadiazine and trimethoprim after intravenous (i.v.) and intramuscular (i.m.) administration of a sulphadiazine/trimethoprim (5:1) combination in sheep. Sulphadiazine bioavailability (+/-SD) was 69.00%+/-10.51%. The half-life of the terminal phase (4.10+/-0.58 h after i. v., and 4.03+/-0.31 h after i.m. administration) was significantly higher than the respective value for trimethoprim (0.59+/-0.19 h) after i.v. administration. The maintenance of a constant plasma concentration ratio after i.v. administration was therefore impossible. The acetylation capacity in sheep, determined by the AUC ratio between N4-acetylsulphadiazine and the parent compound, sulphadiazine, was very low (less than 4%). The most remarkable finding of this study was that trimethoprim was not detected in sheep plasma after i.m. injection. In conclusion, according to the findings of the present study, following i.v. administration of the sulphadiazine/t...Continue Reading

References

Sep 1, 1978·Zentralblatt für Veterinärmedizin. Reihe A·M AtefK Fahd
Feb 1, 1975·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Nov 1, 1977·Acta Pharmacologica Et Toxicologica·O Ladefoged
Feb 1, 1976·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Feb 1, 1976·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Oct 1, 1975·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Jan 31, 1976·The Veterinary Record·G R Craig, G White
Sep 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·W LöscherM Kietzmann
Jun 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·N W KnoppertA S van Miert
Dec 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·S E ShoafC L Guard
May 1, 1968·British Journal of Pharmacology and Chemotherapy·S R Bushby, G H Hitchings
Jul 11, 1970·The Veterinary Record·M Barnett, S R Bushby
Sep 1, 1981·Journal of Veterinary Pharmacology and Therapeutics·S A YoussefS A Salam
Dec 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·E van DuijkerenA S van Miert
Aug 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·A S van Miert
Feb 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·E Van DuijkerenA S Van Miert
Mar 1, 1993·Journal of Veterinary Pharmacology and Therapeutics·J F NouwsM Degen
Dec 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·S GarwackiM Zaremba
May 9, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·G C BatziasG Kounenis
Dec 18, 2002·Journal of Veterinary Pharmacology and Therapeutics·C GrekoJ Luthman
Jul 23, 2003·Veterinary Research Communications·K BaertP De Backer

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Citations

Jun 12, 2013·European Journal of Drug Metabolism and Pharmacokinetics·Myung-Jin ChoiSeung-Chun Park
Jan 18, 2017·Journal of Veterinary Pharmacology and Therapeutics·Y-F LiZ-L Zeng
Dec 29, 2007·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Burkhard SchmidtAndreas Schäffer

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