Bioavailability of alpha-tocopherol stereoisomers in rats depends on dietary doses of all-rac- or RRR-alpha-tocopheryl acetate

The British Journal of Nutrition
S K JensenC Lauridsen

Abstract

The biological function of the stereoisomers of alpha-tocopherol is believed to depend on their bioavailability. Assessment of bioavailability within the body is therefore considered to be a good and easy way to predict biological value. The separation of alpha-tocopherol methyl ethers by chiral column HPLC is a good and easy tool with which to study the distribution of alpha-tocopherol stereoisomers. The objective of this investigation was to evaluate the bioavailability and distribution of the stereoisomers of alpha-tocopherol in the plasma and tissue in growing rats fed 25, 50, 100 or 200 mg/kg diet of either RRR- or all-rac-alpha-tocopheryl acetate for 10 d. The ratio between the two vitamin E sources based on their alpha-tocopherol concentration in plasma and tissues varied in the plasma between 1.04 and 1.74 and in tissues, ratios of 0.84-1.24 for liver, 0.34-1.59 for lung and 0.75-1.50 for spleen were obtained. An increasing dietary level of all-rac-alpha-tocopheryl acetate decreased the proportion of RRR-alpha-tocopherol, whereas the other stereoisomers were not affected. RRS-alpha-Tocopherol was present in the highest proportion, followed by RSR-, RSS- and RRR-alpha-tocopherol. In contrast to the other tissues and plas...Continue Reading

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Citations

Aug 12, 2009·Journal of Animal Physiology and Animal Nutrition·Y Dersjant-Li, M Peisker
May 18, 2016·The British Journal of Nutrition·Matthew J KuchanJacqueline C Lieblein-Boff
Feb 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju-Yen FuLay-Hong Chuah
Aug 25, 2018·Current Developments in Nutrition·Matthew J KuchanSheila M Innis
Dec 28, 2018·Animal : an International Journal of Animal Bioscience·L N LealJ Martín-Tereso
Jan 31, 2021·Scientific Reports·Saman LashkariSøren K Jensen
May 1, 2021·Animals : an Open Access Journal From MDPI·Satoshi HagaSanggun Roh

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