PMID: 8602592Mar 1, 1996Paper

Bioavailability of calcium supplements and the effect of Vitamin D: comparisons between milk, calcium carbonate, and calcium carbonate plus vitamin D

The American Journal of Clinical Nutrition
L Mortensen, P Charles

Abstract

Our aim was to examine a regimen for calcium supplementation because various factors seem to be important for its bioavailability, and to examine the effect of adding vitamin D to the supplement. The participants were 20 healthy women aged 28-59 y (chi: 38 y). During the 3-d periods and 1 d before, the participants were consuming a calcium and energy-balanced diet as similar to their usual daily diet as possible. The study was designed as a randomized, placebo-controlled, partly blinded crossover study divided into four periods of 3 d each: 1) three tablets containing 1000 mg CaCO3/d, 2) three tablets containing 1000 mg CaCO3 plus 5 micrograms (200 IU) vitamin D/d, 3)1 L more milk than in the usual daily diet, and 4) three placebo tablets daily. Bioavailability of the different calcium-supplement regimens were evaluated by changes in 24-h urinary excretion of calcium, phosphate, and magnesium. A significant increase in urinary calcium excretion was found during all periods of supplementation compared with the placebo period (P<0.01). Excretion of calcium in the calcium carbonate period was not significantly higher that that in the milk period, but calcium carbonate plus vitamin D resulted in significantly higher calcium excreti...Continue Reading

Citations

Aug 28, 2001·The American Journal of Clinical Nutrition·M U KärkkäinenM Välimäki
Feb 18, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Sanjana Vijay NemadeSayali Jayant Sonkhedkar
Jul 27, 1999·The Journal of International Medical Research·F Celotti, A Bignamini
Apr 29, 2004·European Journal of Clinical Nutrition·J Tfelt-Hansen, O Tørring
Feb 14, 2006·The American Journal of Clinical Nutrition·Eduardo López-HuertasSusan Fairweather-Tait
Apr 2, 2009·The British Journal of Nutrition·Jean-Philippe BonjourConnie M Weaver
Feb 1, 2019·Nature Communications·Xinyue LiuXuanhe Zhao
Apr 12, 2000·Journal of the American College of Nutrition·L Guéguen, A Pointillart
Oct 22, 2011·International Journal of Food Sciences and Nutrition·Neha J SanwalkaM Zulf Mughal
Dec 18, 2014·Calcified Tissue International·Ulla Kristine MøllerLars Rejnmark
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·R P HeaneyM F Holick
May 15, 2001·Journal of the American College of Nutrition·G D MillerL D McBean
Apr 4, 2003·Journal of the American College of Nutrition·Robert P HeaneyAdrianne Bendich
Jun 20, 2017·Journal of the American College of Nutrition·Theresa GreupnerAndreas Hahn
Mar 28, 2002·Pharmacology & Therapeutics·M A Rodríguez-Martínez, E C García-Cohen

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