PMID: 9181604May 1, 1997Paper

Bioavailability of enrofloxacin after oral administration to fed and fasted pigs

Pharmacology & Toxicology
P Nielsen, N Gyrd-Hansen

Abstract

The disposition of enrofloxacin was measured after intravenous and oral administration to pigs. Eight clinically healthy pigs weighing 25 to 40 kg received a dose of 5 mg/kg intravenously and 10 mg/kg orally in both a fasted and a fed condition in a three-way cross-over design. Enrofloxacin was present in plasma for up to 72 hr after both intravenous and oral administration to fasted as well as fed pigs. The steady state volume of distribution was determined to 3.9 +/- 0.5 1/kg body weight which indicates that enrofloxacin was widely distributed in the body. The bioavailability was determined to 83 +/- 13% in fed and to 101 +/- 32% in fasted pigs. Based on the bioavailability and the resulting plasma concentrations it is concluded that a therapeutically active concentration for the most common porcine microbial pathogens are maintained for at least 24 hr after oral administration of 10 mg/kg body weight to fasted as well as to fed pigs. Ciprofloxacin which is an active metabolite of enrofloxacin was observed in plasma samples from all treated pigs, but the concentration never exceeded 0.1 microgram/ml. During the first 24 hr after the administration of enrofloxacin the concentration of the metabolite made up less than 10% of th...Continue Reading

References

Aug 1, 1978·The Journal of Pharmacy and Pharmacology·D J Cutler
Aug 1, 1979·Journal of Pharmaceutical Sciences·L Z Benet, R L Galeazzi
Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Apr 1, 1992·Clinical Pharmacokinetics·J D Baggot
Jul 1, 1990·Clinical Pharmacology and Therapeutics·D K YuD H Giesing
Jan 1, 1988·Infection·T BerganR Rohwedder
Apr 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·P Nielsen, N Gyrd-Hansen
Jan 1, 1994·Research in Veterinary Science·P Nielsen, N Gyrd-Hansen
Oct 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·L KaartinenS Pyörälä
Apr 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·M Gips, S Soback
Aug 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·P Nielsen, N Gyrd-Hansen

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Citations

May 19, 2004·Archives of Toxicology·Jung Hae YoonJaroslava Halper
Feb 1, 2006·Archives of Environmental Contamination and Toxicology·N Suresh BabuV Ranganathan
Apr 15, 2004·International Journal of Antimicrobial Agents·Julie SunderlandAnne A Delsol
Dec 7, 2000·Journal of Veterinary Pharmacology and Therapeutics·D L FrazierE I Evans
May 10, 2002·Journal of Veterinary Pharmacology and Therapeutics·M CouletJ Lohuis
Nov 9, 2002·Journal of Veterinary Pharmacology and Therapeutics·C WiuffO Svendsen
Jan 3, 2012·Environmental Toxicology and Pharmacology·Starling KalpanaJitendra K Malik
Aug 19, 2007·Research in Veterinary Science·Anu RahalJ K Malik
Oct 30, 2015·Veterinary Research·Nubia MacedoMontserrat Torremorell
Jun 11, 2004·Journal of Veterinary Pharmacology and Therapeutics·S K CoxJ Bartges
Jul 19, 2006·Journal of Veterinary Pharmacology and Therapeutics·A RahalV Ahuja
Nov 14, 2013·Journal of Veterinary Pharmacology and Therapeutics·L A BlackM Govendir
Dec 30, 2006·Veterinary Microbiology·Anne Kruse LykkebergLars Bogø Jensen
Sep 1, 2006·Environmental Toxicology and Pharmacology·N Suresh BabuV Ranganathan
Sep 14, 2015·Environmental Toxicology and Pharmacology·Starling KalpanaJitendra K Malik
Dec 13, 2005·American Journal of Veterinary Research·Carlos R SanchezMark G Papich
Jan 19, 2019·Journal of Veterinary Pharmacology and Therapeutics·Marion LeiberichVinny Naidoo
Jan 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lynn O PostMichael J Myers
Nov 26, 2015·The Journal of Veterinary Medical Science·Nitwarat RuennarongSaranya Poapolathep
Jun 20, 2020·The Veterinary Journal·Dominiek MaesAnne V Gautier-Bouchardon

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