Abstract
Eurycoma longifolia is one of the commonly consumed herbal preparations and its major chemical compound, eurycomanone, has been described to have antimalarial, antipyretic, aphrodisiac, and cytotoxic activities. Today, the consumption of E. longifolia is popular through the incorporation of its extract in food items, most frequently in drinks such as tea and coffee. In the current study, the characterisation of the physicochemical and pharmacokinetic (PK) attributes of eurycomanone were conducted via a series of in vitro and in vivo studies in rats and mice. The solubility and chemical stability of eurycomanone under the conditions of the gastrointestinal tract environment were determined. The permeability of eurycomanone was investigated by determining its distribution coefficient in aqueous and organic environments and its permeability using the parallel artificial membrane permeability assay system and Caco-2 cultured cells. Eurycomanone's stability in plasma and its protein-binding ability were measured by using an equilibrium dialysis method. Its stability in liver microsomes across species (mice, rat, dog, monkey, and human) and rat liver hepatocytes was also investigated. Along with the PK evaluations of eurycomanone in ...Continue Reading
References
Sep 1, 1991·Journal of Natural Products·L B KardonoA D Kinghorn
Apr 1, 1986·Planta medica·K L ChanD C Warhurst
Apr 1, 1995·Planta medica·H H AngJ W Mak
Aug 17, 2001·Phytotherapy Research : PTR·H H AngE K Gan
Sep 21, 2001·Fundamental & Clinical Pharmacology·H H Ang, T H Ngai
Aug 7, 2002·Clinical Pharmacokinetics·Michael S RobertsMichael Weiss
Jan 24, 2004·Bioorganic & Medicinal Chemistry·Ping-Chung KuoTian-Shung Wu
Oct 6, 2005·Planta medica·Bin-Seng LowKit-Lam Chan
Jan 27, 2007·Planta medica·K L ChanH Itokawa
Jun 11, 2009·Cancer Cell International·Yusmazura ZakariaPeter J Houghton
Dec 29, 2009·Wiener klinische Wochenschrift·Walther H WernsdorferGunther Wernsdorfer
Nov 19, 2009·Journal of Natural Products·Katsunori MiyakeShigetoshi Kadota
Jul 29, 2010·Planta medica·Chin-Hoe TehKit-Lam Chan
Sep 9, 2010·Molecular Pharmaceutics·Deanna M MudieGregory E Amidon
Mar 4, 2011·Journal of Chromatography. a·Chin-Hoe TehKit-Lam Chan
Sep 10, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Pooi-Fong WongSazaly AbuBakar
Nov 29, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lee Suan ChuaRamlan Abdul Aziz
Dec 25, 2012·Journal of Ethnopharmacology·Bin-Seng LowKit-Lam Chan
Mar 8, 2013·Andrologia·M C SolomonR R Henkel
Jul 3, 2013·Journal of Ethnopharmacology·Bin-Seng LowKit-Lam Chan
Jul 25, 2013·Journal of Natural Medicines·Yan PanChin Eng Ong
Sep 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shéhérazade HajjouliMarc Diederich
Apr 29, 2015·Journal of Separation Science·Young Min HanHye Hyun Yoo
Mar 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaheed Ur RehmanHye Hyun Yoo
Aug 31, 2016·Biomedical Chromatography : BMC·Shaheed Ur RehmanHye Hyun Yoo
Oct 27, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Stephan T SternDavid M Stevens
Citations
Oct 18, 2020·Nutrients·Norzahirah AhmadHussin Muhammad
Feb 14, 2021·Pharmaceuticals·Bee Ping TehHussin Muhammad
Mar 9, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Nur Amanina Abd AzizMohamad Khairul Hafiz Idris
Apr 2, 2021·The Journal of Pharmacy and Pharmacology·Wan-Jie ChungChong-Yew Lee
Dec 22, 2020·ACS Pharmacology & Translational Science·Shyam H KambleChristopher R McCurdy