Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

Pharmaceutics
Norzahirah AhmadAmi Fazlin Syed Mohamed

Abstract

Eurycoma longifolia is one of the commonly consumed herbal preparations and its major chemical compound, eurycomanone, has been described to have antimalarial, antipyretic, aphrodisiac, and cytotoxic activities. Today, the consumption of E. longifolia is popular through the incorporation of its extract in food items, most frequently in drinks such as tea and coffee. In the current study, the characterisation of the physicochemical and pharmacokinetic (PK) attributes of eurycomanone were conducted via a series of in vitro and in vivo studies in rats and mice. The solubility and chemical stability of eurycomanone under the conditions of the gastrointestinal tract environment were determined. The permeability of eurycomanone was investigated by determining its distribution coefficient in aqueous and organic environments and its permeability using the parallel artificial membrane permeability assay system and Caco-2 cultured cells. Eurycomanone's stability in plasma and its protein-binding ability were measured by using an equilibrium dialysis method. Its stability in liver microsomes across species (mice, rat, dog, monkey, and human) and rat liver hepatocytes was also investigated. Along with the PK evaluations of eurycomanone in ...Continue Reading

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Citations

Oct 18, 2020·Nutrients·Norzahirah AhmadHussin Muhammad
Mar 9, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Nur Amanina Abd AzizMohamad Khairul Hafiz Idris
Dec 22, 2020·ACS Pharmacology & Translational Science·Shyam H KambleChristopher R McCurdy

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Methods Mentioned

BETA
Assay
equilibrium dialysis

Software Mentioned

GraphPad
GraphPad Prism
Phoenix TM WinNolin®

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