Bioavailability of iron and zinc from a multiple micronutrient-fortified beverage

The Journal of Pediatrics
Ana M Avalos MishaanSteven A Abrams

Abstract

To test the hypothesis that micronutrient beverages can provide the daily iron and zinc needs of small children. Forty children aged 6 to 9 years were recruited (Lima, Peru). For 4 weeks, they received a daily serving of a beverage containing multiple micronutrients. Over 2 consecutive days, subjects received stable isotope-labeled servings of the beverage with and without a meal as well as an intravenous dose of zinc. Iron and zinc bioavailability were assessed using mass spectrometry. Iron absorption was significantly lower with a meal than without (9.8 +/- 6.7% versus 11.6 +/- 6.9%, P=.04), but zinc absorption was not (24.5 +/- 10.7% versus 22.8 +/- 7.6%, P=.2). In either case, however, a single daily serving provided most of the iron and zinc requirements for the children. Single daily servings of multinutrient-fortified beverages can meet much of the mineral needs for small children. Food has a small inhibitory effect on iron, but not zinc, absorption; therefore, these beverages can be efficacious even when given with a meal.

References

Aug 27, 1998·Journal of Tropical Pediatrics·R Moy
Dec 22, 1999·The Proceedings of the Nutrition Society·R K Chandra
Jun 2, 2001·Parasitology·L S StephensonE A Ottesen

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Citations

Jan 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jay MorrisKendal D Hirschi
Feb 12, 2010·The American Journal of Clinical Nutrition·Conrad R ColeThomas R Ziegler
Feb 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeeyon Jeong, Mary Lou Guerinot
Dec 19, 2019·The Cochrane Database of Systematic Reviews·Jai K DasZulfiqar A Bhutta
Nov 9, 2004·The American Journal of Clinical Nutrition·Steven A Abrams
May 29, 2009·Food and Nutrition Bulletin·Sonja Y Hess, Kenneth H Brown
Jul 9, 2005·The American Journal of Clinical Nutrition·Donald Short

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