PMID: 6661511Oct 1, 1983Paper

Bioavailability of medroxalol in man

Biopharmaceutics & Drug Disposition
F J KeeleyR A Okerholm

Abstract

Ten healthy male volunteers received single oral doses of 100 mg of medroxalol administered as a solution, a preliminary tablet formulation and a single dose of 100 mg administered intravenously in a randomized three-way crossover study. Mean terminal half-lives of 12.4, 13.4, and 11.3 h were observed for the intravenous, solution and tablet formulation, respectively. Mean urinary recovery of parent drug at 48 h was 8.9 per cent, 3.9 per cent, and 3.2 per cent. Absolute bioavailability estimated from plasma AUC was 54 per cent for the solution and 38 per cent for the tablet, and the relative bioavailability from the tablet was 71 per cent.

References

Mar 1, 1982·The Journal of Pharmacy and Pharmacology·J K Woodward, H C Cheng
Mar 1, 1981·Journal of Cardiovascular Pharmacology·R C DageJ K Woodward

Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·E J Ariëns
Oct 1, 1986·Medicinal Research Reviews·E J Ariëns
Apr 1, 1988·Medicinal Research Reviews·E J Ariëns
Jan 1, 1997·International Journal of Health Services : Planning, Administration, Evaluation·R SørensenJ Grytten
Jun 12, 2021·Critical Care : the Official Journal of the Critical Care Forum·Josée BouchardEXTRIP workgroup

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