PMID: 7334938Dec 1, 1981Paper

Bioavailability of oestradiol and oestriol administered orally to oophorectomized women

Maturitas
B J Fink, M S Christensen

Abstract

A bioavailability study was performed on ten oophorectomized women in a randomized cross-over design. The absorption of tablets containing 2 mg of micronized oestradiol and 1 mg of micronized oestriol (Estrofem) was compared to the absorption of the same micronized hormones administered in an aqueous suspension. Serum concentration values of oestradiol, oestriol and oestrone were measured by radioimmunoassay. The data obtained were analyzed both by univariate and multivariate analyses, and neither the serum concentrations at the various sample times, the maximum concentrations, the times for the maximum concentrations, nor the areas under the serum concentration curves disclosed any significant differences between the tablet and suspension administrations at the 5% level. The serum concentration values achieved by giving 2 mg of oestradiol and 1 mg of oestriol were of the same magnitude or higher than those of the normal menstrual cycle.

References

Jan 1, 1977·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·D E Englund, E D Johansson
Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·C FloodC Longcope
Jun 1, 1968·The Journal of Clinical Endocrinology and Metabolism·M Levitz, J Katz
Dec 1, 1972·Acta Endocrinologica·L E Edqvist, E D Johansson

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Citations

Apr 1, 1984·Journal of Steroid Biochemistry·H Adlercreutz, J Vähäpassi
Apr 6, 2004·Maturitas·Herjan J T Coelingh Bennink
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea GogosMaarten van den Buuse
May 13, 2009·Maturitas·Herjan J T Coelingh Bennink
Dec 1, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John W SchmidtLinda S Kim
Jun 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·B W HartmannJ C Huber
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David A MankoffKenneth A Krohn

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