Bioavailability of suppository acetaminophen in healthy and hospitalized ill dogs

Journal of Veterinary Pharmacology and Therapeutics
E R SikinaB KuKanich

Abstract

To determine the plasma pharmacokinetics of suppository acetaminophen (APAP) in healthy dogs and clinically ill dogs. This prospective study used six healthy client-owned and 20 clinically ill hospitalized dogs. The healthy dogs were randomized by coin flip to receive APAP orally or as a suppository in crossover study design. Blood samples were collected up to 10 hr after APAP dosing. The hospitalized dogs were administered APAP as a suppository, and blood collected at 2 and 6 hr after dosing. Plasma samples were analyzed by ultra-performance liquid chromatography with triple quadrupole mass spectrometry. In healthy dogs, oral APAP maximal concentration (CMAX =2.69 μg/ml) was reached quickly (TMAX =1.04 hr) and eliminated rapidly (T1/2 = 1.81 hr). Suppository APAP was rapidly, but variably absorbed (CMAX =0.52 μg/ml TMAX =0.67 hr) and eliminated (T1/2  = 3.21 hr). The relative (to oral) fraction of the suppository dose absorbed was 30% (range <1%-67%). In hospitalized ill dogs, the suppository APAP mean plasma concentration at 2 hr and 6 hr was 1.317 μg/ml and 0.283 μg/ml. Nonlinear mixed-effects modeling did not identify significant covariates affecting variability and was similar to noncompartmental results. Results supported...Continue Reading

References

Jun 15, 1984·Toxicology and Applied Pharmacology·M C SavidesH W Leipold
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Feb 21, 2016·Journal of Veterinary Pharmacology and Therapeutics·B KuKanich
Jul 21, 2010·Pharmaceuticals·Walter H Hörl

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Citations

Jul 14, 2020·Journal of Veterinary Pharmacology and Therapeutics·Kate KuKanichHyun Joo
Jul 21, 2021·Veterinary Anaesthesia and Analgesia·M M GranadosJuan Manuel Serrano-Rodríguez
Nov 14, 2021·American Journal of Veterinary Research·Melanie MadsenMark G Papich

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