Bioavailability of the ferulic acid-derived phenolic compounds of a rice bran enzymatic extract and their activity against superoxide production

Food & Function
Cristina Perez-TerneroMaria-Dolores Herrera

Abstract

Rice bran is an exceptional source of such antioxidant molecules as γ-oryzanol and ferulic acid, but their bioavailability and metabolism within this matrix remain unknown. The aims of this work were to describe the oral bioavailability and metabolic pathways of the ferulic acid-derived phenolic compounds contained in a rice bran enzymatic extract (RBEE), and to determine its effect on NADPH oxidase activity. Wistar rats were administered with RBEE and sacrificed at different times over a period of 24 h to obtain plasma. An additional group was used for collection of urine and faeces over a period of 48 h. The phenolic metabolites were determined by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS), and plasma pharmacokinetic parameters were calculated. In parallel, aortic rings were incubated in the plasma of rats sacrificed 30 min after RBEE gavage, or in the presence of RBEE, ferulic acid or γ-oryzanol. Endothelin-1-induced superoxide production was recorded by lucigenin-enhanced luminescence. Twenty-five ferulic acid metabolites showing biphasic behaviour were found in the plasma, most of which were found in the urine as well, while in the faeces, colonic metabolism led to simpler phen...Continue Reading

References

Feb 1, 1983·Chemical & Pharmaceutical Bulletin·S FujiwaraN Awata
May 23, 2001·Free Radical Biology & Medicine·A R RechnerC A Rice-Evans
Nov 21, 2001·Journal of Agricultural and Food Chemistry·M F AndreasenM T Garcia-Conesa
Sep 18, 2003·Journal of Agricultural and Food Chemistry·Sandra M KernMaria-Teresa Garcia-Conesa
Jan 28, 2004·Free Radical Biology & Medicine·Andreas R RechnerCatherine A Rice-Evans
May 29, 2004·Current Opinion in Lipidology·Richard E Ostlund
Jun 9, 2005·Journal of Agricultural and Food Chemistry·Zhaohui ZhaoHiroo Sanada
Sep 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M-P GonthierA-M Aura
Jun 11, 2009·British Journal of Pharmacology·Vijay Sharma, John H McNeill
Jun 25, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E Y KwonM S Choi
Sep 6, 2011·Critical Reviews in Food Science and Nutrition·Cynthia Fabian, Yi-Hsu Ju
May 23, 2012·Journal of Agricultural and Food Chemistry·Eszter Mandak, Laura Nyström
Aug 2, 2013·BioFactors·Iziar A LudwigCrozier Alan
Dec 24, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M L JustoR Rodriguez-Rodriguez
Jun 21, 2014·Food & Function·Angélique StalmachAlan Crozier
Oct 24, 2014·Journal of Agricultural and Food Chemistry·Juana I MoseleMaría-José Motilva
Dec 30, 2014·Molecular Nutrition & Food Research·Gema Pereira-CaroAlan Crozier
Jun 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali GhasemzadehAmin Tayebi-Meigooni
Aug 13, 2015·European Journal of Nutrition·Maria Luisa JustoRosalía Rodríguez-Rodríguez

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Citations

Oct 30, 2019·Food & Function·Gabriele Serreli, Monica Deiana
Nov 27, 2019·Future Medicinal Chemistry·Premkumar JayarajRajagopal Desikan
Apr 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John F Lechner, Gary D Stoner
Jan 8, 2021·Foods·Marco SpaggiariMaría Dolores Del Castillo Bilbao
Jun 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tapan BehlSimona Bungau
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Nidia Valenzuela-GrijalvaHumberto González-Ríos
Jun 27, 2019·Journal of Agricultural and Food Chemistry·Diogo CarregosaCláudia N Santos
Oct 10, 2019·Journal of Agricultural and Food Chemistry·Fuqiong ZhouLei Bi

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