Bioavailability of TNT residues in composts of TNT-contaminated soil

Journal of Toxicology and Environmental Health
W G PalmerD A Creasia

Abstract

Composting is being explored as a means to remediate 2,4,6-trinitrotoluene (TNT) contaminated soils. This process appears to modify TNT and to bind it to organic matter. The health hazards associated with dusts generated from such materials cannot be predicted without knowing if the association between TNT residues and compost particulate is stable in biological systems. To address this question, single doses of [14C]-TNT, soil spiked with [14C]-TNT, or compost generated with [14C]-TNT-spiked soils were administered to rats by intratracheal instillation. The appearance of 14C in urine and tissues was taken as an indication of the bioavailability of TNT residues from compost particles. In rats instilled with neat [14C]-TNT, about 35% of the 14C dose appeared in urine within 3 d. The 14C excreted in urine by these rats decreased rapidly thereafter, and was undetectable by 4 wk after treatment. Similar results were obtained with soil-treated rats. In contrast, after treatment with [14C]-TNT-labeled compost, only 2.3% of the total 14C dose appeared in urine during the first 3 d. Low levels of 14C continued to be excreted in urine from compost-treated rats for more than 6 mo, and the total amount of 14C in urine was comparable to th...Continue Reading

References

Jun 1, 1976·Applied and Environmental Microbiology·N G McCormickH S Levinson
Aug 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B S LevineP M Lish
Jul 1, 1986·British Journal of Industrial Medicine·B H WoollenG T Steel
Sep 1, 1982·Applied and Environmental Microbiology·D L Kaplan, A M Kaplan

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Citations

Mar 16, 2004·Journal of Environmental Management·Thomas A LewisRonald L Crawford
May 16, 2001·Environmental Toxicology and Chemistry·C Achtnich, H Lenke

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