Bioavailability study of arsenic and mercury in traditional Chinese medicines (TCM) using an animal model after a single dose exposure

Regulatory Toxicology and Pharmacology : RTP
Ujang TinggiAlan Seawright

Abstract

Traditional Chinese medicines (TCM) are increasingly being used as alternative medicines in many countries, and this has caused concern because of adverse health effects from toxic metal bioavailability such as mercury (Hg) and arsenic (As). The aim of this study was to investigate the bioavailability of As and Hg from TCM after a single exposure dose using an animal model of female Sprague-Dawley rats. The rats were divided into 6 groups which included four groups treated with sodium arsenite (NaAsO2), arsenic sulfide (As2S3), mercuric chloride (HgCl2), mercuric sulfide (HgS), and two groups treated with TCM containing high Hg or As (Liu Shen Wan: As 7.7-9.1% and Hg 1.4-5.0%; Niuhang Jie du Pian: As 6.2-7.9% and Hg <0.001%). The samples of urine, faeces, kidney and liver were collected for analysis and histological assay. The results indicated that relatively low levels of As and Hg from these TCM were retained in liver and kidney tissues. The levels of As in these tissues after TCM treatment were consistent with the levels from the As sulphide treated group. With the exception of the mercuric chloride treated group, the levels of Hg in urine from other groups were very low, and high levels of As and Hg from TCM were excreted ...Continue Reading

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Citations

Apr 2, 2016·Regulatory Toxicology and Pharmacology : RTP·Qin WuJie Liu
Jul 9, 2020·Metallomics : Integrated Biometal Science·Lujing GengHongtao Bi
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jie LiuLi-Xin Wei
Feb 8, 2019·Journal of Forensic Sciences·Ping LuHai-Mei Zhou
Sep 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wenfeng XuPengfei Jin

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