Abstract
Traditional Chinese medicines (TCM) are increasingly being used as alternative medicines in many countries, and this has caused concern because of adverse health effects from toxic metal bioavailability such as mercury (Hg) and arsenic (As). The aim of this study was to investigate the bioavailability of As and Hg from TCM after a single exposure dose using an animal model of female Sprague-Dawley rats. The rats were divided into 6 groups which included four groups treated with sodium arsenite (NaAsO2), arsenic sulfide (As2S3), mercuric chloride (HgCl2), mercuric sulfide (HgS), and two groups treated with TCM containing high Hg or As (Liu Shen Wan: As 7.7-9.1% and Hg 1.4-5.0%; Niuhang Jie du Pian: As 6.2-7.9% and Hg <0.001%). The samples of urine, faeces, kidney and liver were collected for analysis and histological assay. The results indicated that relatively low levels of As and Hg from these TCM were retained in liver and kidney tissues. The levels of As in these tissues after TCM treatment were consistent with the levels from the As sulphide treated group. With the exception of the mercuric chloride treated group, the levels of Hg in urine from other groups were very low, and high levels of As and Hg from TCM were excreted ...Continue Reading
References
Feb 1, 1987·Environmental Research·E Marafante, M Vahter
Sep 1, 1983·The Science of the Total Environment·M VahterL Dencker
Sep 21, 1995·The New England Journal of Medicine·E O EspinozaB Bleasdell
Feb 1, 1994·Environmental Health Perspectives·K GroenR F Vlug
Dec 24, 1997·Risk Analysis : an Official Publication of the Society for Risk Analysis·D J PaustenbachP Chrostowski
Dec 24, 1997·Risk Analysis : an Official Publication of the Society for Risk Analysis·R A Schoof, J B Nielsen
Aug 26, 1998·The Analyst·J C NgM R Moore
May 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephen M RobertsRaymond J Bergeron
Sep 24, 2004·Pharmacoepidemiology and Drug Safety·E Ernst
Dec 21, 2004·Health Policy·Shen-Kuan YeePeck-Lin Choo
Jan 10, 2006·The Science of the Total Environment·Ling-Chu ChienBor-Cheng Han
Jan 24, 2007·Toxicology and Applied Pharmacology·Iris KochWilliam R Cullen
Aug 21, 2007·Toxicology and Applied Pharmacology·Chun-Fa HuangShoei-Yn Lin-Shiau
Sep 1, 2007·Journal of Toxicology and Environmental Health. Part a·Kelli CooperStephen Myers
May 9, 2008·The Journal of Pharmacology and Experimental Therapeutics·Jie LiuMichael P Waalkes
Oct 22, 2008·Lancet·Jin-Ling TangKan-Wen Ma
Dec 24, 2008·Environmental Geochemistry and Health·Matthew ReesTim Kuchel
Jul 6, 2010·Journal of Ethnopharmacology·Xinrui ZhouKui Wang
Nov 26, 2010·Chemico-biological Interactions·Yuan-Fu LuJing-Shan Shi
Dec 4, 2010·Toxicology Letters·Jing-Zhen ShiY James Kang
Mar 26, 2011·Regulatory Toxicology and Pharmacology : RTP·Yuan-Fu LuJie Liu
Jan 1, 2010·Journal of Analytical Atomic Spectrometry·Innocent JayawardeneChitra Amarasiriwardena
Aug 10, 2011·The Science of the Total Environment·Eric S J HarrisDavid M Eisenberg
Aug 26, 2011·The Science of the Total Environment·Iris KochKenneth J Reimer
Sep 7, 2011·Current Drug Metabolism·Thomas Efferth, Bernd Kaina
Oct 16, 2012·Environmental Pollution·Xiao-Juan LiuWen-Ju Liu
Jan 1, 2011·ISRN Toxicology·Jia-Wei MiaoAn-Sheng Sun
Jun 15, 2013·Environmental Science and Pollution Research International·Jack C NgRavi Naidu
Citations
Apr 2, 2016·Regulatory Toxicology and Pharmacology : RTP·Qin WuJie Liu
Oct 25, 2016·Toxicology Letters·Jie LiuLi-Xin Wei
Feb 6, 2017·Talanta·Xiao-Ping LuWang-Bing Zhang
Jul 9, 2020·Metallomics : Integrated Biometal Science·Lujing GengHongtao Bi
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jie LiuLi-Xin Wei
Jul 17, 2020·Journal of Separation Science·Na LiPengfei Tu
May 24, 2017·Biological Research·Peng ChenHongyu Li
Feb 8, 2019·Journal of Forensic Sciences·Ping LuHai-Mei Zhou
Jan 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wenfeng XuPengfei Jin
Sep 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wenfeng XuPengfei Jin
Jun 14, 2019·Frontiers in Pharmacology·Bun TsoiJiangang Shen
May 26, 2017·Toxicology and Applied Pharmacology·Bin-Bin ZhangJie Liu
Aug 30, 2021·Journal of Hazardous Materials·Xiaoman ZhengMinghua Gu