Abstract
Corydalis saxicola Bunting (Yanhuanglian) is an important component in various prescriptions in traditional Chinese medicine. Yanhuanglian has been demonstrated to possess many pharmacological activities, including antibacterial, antiviral and anticancer activities. The active fractions are dehydrocavidine, coptisine, dehydroapocavidine and tetradehydroscoulerine. The purpose of the present study was to examine in vivo pharmacokinetics and tissue distribution in rats by using high-performance liquid chromatography (HPLC) coupled with tandem mass spectrometry. Systemic clearance of the four active alkaloids in plasma was over 93% of hepatic blood flow, indicating they may be quickly eliminated via hepatic clearance. Less than 10% drugs was excreted via urine following intravenous and oral administration, suggesting that these four alkaloids may undergo significant metabolism in the body or the drug may be excreted via other routes other than urine. There was significantly lower excretion of these four alkaloids following oral than intravenous administration, suggesting a significant first pass effect after oral administration. There appeared to be wide distribution of those four alkaloids in rats as demonstrated by the higher ap...Continue Reading
Citations
Aug 26, 2010·Biological Trace Element Research·Nazia UzmaK I Priyadarsini
Jul 12, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Chien-Ming LiJames T Dalton
Dec 4, 2008·The American Journal of Chinese Medicine·Lindsey N JacksonB Mark Evers
Aug 19, 2014·International Journal of Antimicrobial Agents·T P Tim CushnieAndrew J Lamb
Oct 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiu-Yue LiYue Shi
Dec 17, 2009·Drug and Chemical Toxicology·Zhu JiangboZhang Tianbao
Nov 1, 2015·Journal of Pharmaceutical and Biomedical Analysis·Minlu ChengLi Ding
Mar 25, 2008·Journal of Ethnopharmacology·Tao WangChuan Zhang
Sep 7, 2011·Journal of Ethnopharmacology·Tao WangBo-Jun Yuan
Nov 9, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Bin ZhangHengshan Wang
Dec 14, 2016·Biomedical Chromatography : BMC·Yu YanGuanhua Du
Jul 5, 2018·Biomedical Chromatography : BMC·Guoliang DaiWenzheng Ju
Nov 13, 2008·Phytotherapy Research : PTR·Qi QiQinglong Guo
Jun 16, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Eun A KoJae-Hong Ko
Jan 26, 2016·Journal of Separation Science·Lu LiuLijun Wu
Nov 14, 2019·Toxins·Amin ThawabtehRafik Karaman
Oct 21, 2017·Frontiers in Pharmacology·Shi-Jun YueDan Yan
Aug 29, 2021·Pathogens·Paweł KrzyżekSylwia Zielińska