PMID: 9533662Apr 9, 1998Paper

Biobehavioral correlates in migraine: the role of hypersensitivity and information-processing dysfunction

Cephalalgia : an International Journal of Headache
W D Gerber, Jean Schoenen

Abstract

In this paper we address the role of specific abnormal behavioral patterns (such as perfectionism or hypersensitivity) which have been described as psychological characteristics in migraine patients. We propose that behavioral abnormalities may be the result of a determined cortical hypersensitivity and an associated social learning process. New neuro(psycho)physiological data support the concept that migraine is a brainstem-related information-processing dysfunction that is characterized by cortical hypersensitivity and reduced habituation to stimuli. The cortical activity reflects a (time) periodicity and may be due to endogenous or exogenous factors. Based on the current understanding of behavioral and neurophysiological aspects of migraine, we postulate a two-process model of migraine aetiology: (i) a genetically determined hyperactivity of the central monoaminergic (catecholaminergic) system, which could be possibly modulated by learning processes and (ii) a homeostatic (counter) regulation and mobilization of reduced (mitochondrial) energy reserve.

Citations

Apr 26, 2002·Cephalalgia : an International Journal of Headache·S BenderR Oelkers-Ax
Sep 27, 2003·Cephalalgia : an International Journal of Headache·M SiniatchkinU Stephani
Feb 14, 2006·Cephalalgia : an International Journal of Headache·F EbingerD Rating
Feb 11, 2000·Cephalalgia : an International Journal of Headache·P KroppU Stephani
Sep 3, 2003·Cephalalgia : an International Journal of Headache·M SiniatchkinW-D Gerber
Mar 25, 2006·Cephalalgia : an International Journal of Headache·M SiniatchkinW D Gerber
May 19, 2011·Cephalalgia : an International Journal of Headache·Joachim MaierStephan Bender
May 21, 2013·Der Schmerz·G FritscheG Haag
Jun 13, 2012·Journal of Neural Transmission·Peter KroppWolf-Dieter Gerber
Jul 31, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Gunther FritzerJosef Aldenhoff
Feb 8, 2008·Cephalalgia : an International Journal of Headache·R Oelkers-AxM Weisbrod
Apr 17, 2001·Cephalalgia : an International Journal of Headache·M SiniatchkinW D Gerber
Mar 28, 2012·Applied Psychophysiology and Biofeedback·Peter KroppWolf-Dieter Gerber
Apr 28, 2005·Expert Review of Neurotherapeutics·Peter Kropp

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