Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial

Psychosomatic Medicine
James A BlumenthalScott M Palmer

Abstract

To examine the prognostic value of select biobehavioral factors in patients with chronic obstructive pulmonary disease (COPD) in a secondary analysis of participants from the INSPIRE-II trial. Three hundred twenty-six outpatients with COPD underwent assessments of pulmonary function, physical activity, body mass index, inflammation, pulmonary symptoms, depression, and pulmonary quality of life and were followed up for up to 5.4 years for subsequent clinical events. The prognostic value of each biobehavioral factor, considered individually and combined, also was examined in the context of existing Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2011 risk stratification. Sixty-nine individuals experienced a hospitalization or died over a mean follow-up period of 2.4 (interquartile range = 1.6) years. GOLD classification was associated with an increased risk of clinical events (hazard ratio [HR] = 2.72 [95% confidence interval = 1.63-4.54], per stage); 6-minute walk (HR = 0.50 [0.34-0.73] per 500 ft), total steps (HR = 0.82 [0.71-0.94] per 1000 steps), high-sensitivity C-reactive protein (HR = 1.44 [1.01-2.06] per 4.5 mg/l), depression (HR = 1.12 [1.01-1.25] per 4 points), and pulmonary quality of life (HR = 1.73 [1....Continue Reading

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Citations

Mar 14, 2018·Psychosomatic Medicine·Patrick J SmithLaurie D Snyder
Feb 2, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Giovanni LeuzziUgo Pastorino
Nov 20, 2016·Clinical Transplantation·Patrick J SmithScott M Palmer
Sep 14, 2019·Clinical Transplantation·Patrick J SmithLaurie D Snyder
Nov 1, 2021·Annals of Physical and Rehabilitation Medicine·Francesc Medina-MirapeixRoberto Bernabeu-Mora

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