Biocatalytic approaches applied to the synthesis of nucleoside prodrugs

Biotechnology Advances
Luis E IglesiasAdolfo M Iribarren

Abstract

Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome selectivity issues of nucleoside chemistry. In this context, the aim of this review is to give an overview of the opportunities provided by biocatalytic procedures in the preparation of nucleoside prodrugs. The potential of biocatalysis in this research area will be presented through examples covering the different types of nucleoside prodrugs: nucleoside analogues as prodrugs, nucleoside lipophilic prodrugs and nucleoside hydrophilic prodrugs.

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Citations

May 9, 2015·Applied Microbiology and Biotechnology·Jesús Fernández-Lucas
May 21, 2016·Frontiers in Chemistry·María A DellafioreAdolfo M Iribarren
May 18, 2016·Bioscience, Biotechnology, and Biochemistry·Yuuki MitsukawaJun Ogawa
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Jan 16, 2019·Beilstein Journal of Organic Chemistry·Ilja V FateevRoman S Esipov
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