Bioceramic-collagen scaffolds loaded with human adipose-tissue derived stem cells for bone tissue engineering

Molecular Biology Reports
Neda Daei-FarshbafMohsen Norouzian

Abstract

The combination of bioceramics and stem cells has attracted the interest of research community for bone tissue engineering applications. In the present study, a combination of Bio-Oss(®) and type 1 collagen gel as scaffold were loaded with human adipose-tissue derived mesenchymal stem cells (AT-MSCs) after isolation and characterization, and the capacity of them for bone regeneration was investigated in rat critical size defects using digital mammography, multi-slice spiral computed tomography imaging and histological analysis. 8 weeks after implantation, no mortality or sign of inflammation was observed in the site of defect. According to the results of imaging analysis, a higher level of bone regeneration was observed in the rats receiving Bio-Oss(®)-Gel compared to untreated group. In addition, MSC-seeded Bio-Oss-Gel induced the highest bone reconstruction among all groups. Histological staining confirmed these findings and impressive osseointegration was observed in MSC-seeded Bio-Oss-Gel compared with Bio-Oss-Gel. On the whole, it was demonstrated that combination of AT-MSCs, Bio-Oss and Gel synergistically enhanced bone regeneration and reconstruction and also could serve as an appropriate structure to bone regenerative m...Continue Reading

References

Oct 22, 2003·Cell·Etsuko AbeMone Zaidi
Feb 13, 2004·Calcified Tissue International·J A TsaiO Torring
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·John K FraserMarc H Hedrick
Jul 2, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·S LøkenF P Reinholt
Jul 30, 2008·BMJ : British Medical Journal·Bijay Vaidya, Simon H S Pearce
Feb 11, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mohamadreza Baghaban EslaminejadHouri Mivehchi
Jul 2, 2009·Cytotherapy·Jyoti A KodeAnandwardhan A Hardikar
Jan 15, 2010·Clinical Oral Implants Research·Mauricio G AraújoJan Lindhe
Jul 3, 2010·Plastic and Reconstructive Surgery·Yvonne RaskoRoshni Rao
Dec 7, 2010·Journal of Cellular and Molecular Medicine·K ArvidsonA Finne-Wistrand
Nov 15, 2011·The Journal of Surgical Research·Peyman DinarvandMasoud Soleimani
Jan 1, 2010·Oman Medical Journal·Vincenzo SollazzoFrancesco Carinci

❮ Previous
Next ❯

Citations

Apr 5, 2017·Expert Opinion on Biological Therapy·Marta BarbaWanda Lattanzi
May 3, 2018·Journal of Cellular Physiology·Sadegh L MoradiAbdolreza Ardeshirylajimi
Jan 29, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Fatemeh Sadat HosseiniShohreh Zare Karizi
Aug 16, 2016·Journal of Tissue Engineering and Regenerative Medicine·Siddharth ShanbhagAndreas Stavropoulos
Aug 23, 2020·International Journal of Molecular Sciences·Kar Wey YongAlistair C Cowie
Oct 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sadegh Lotfalah MoradiAbdolreza Ardeshirylajimi
Jul 10, 2014·International Orthopaedics·Antonio MarmottiGiuseppe Peretti
May 20, 2015·Science China. Life Sciences·Liang DongXiaoBing Fu
Aug 2, 2018·PloS One·Philippa M BennettJowan G Penn-Barwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.