Sep 28, 2018

Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Manisha J Oza, Yogesh A Kulkarni

Abstract

Biochanin A (5,7-Dihydroxy-4'-methoxyisoflavone) is an O-methylated isoflavone known for its anti-inflammatory, lipid lowering and anti-cancer activity. The current study was designed to find out antidiabetic efficacy of Biochanin A in type 2 diabetes in rats. Induction of type 2 diabetes mellitus in experimental animals was carried out by manipulation of diet using high fat diet for fourteen days and then administration of streptozotocin at low dose of 35 mg/kg, i.p. The diabetic animals were treated with 10, 20 and 40 mg/kg of Biochanin A for 28 days. The effect of Biochanin A treatment in diabetic animals was evaluated by measuring changes in body weight, biochemical parameters, insulin sensitivity index, Homeostatic model assessment-Insulin resistance (HOMA-IR), oral glucose tolerance test, glycohaemoglobin and hepatic glycogen level. Changes in histopathological characteristics of pancreatic tissue were also evaluated after treatment with Biochanin A. Immunohistochemical analysis of pancreatic tissue was carried out for the expression of SIRT1. The results showed that the selected doses of (10, 20 and 40 mg/kg) Biochanin A significantly decreased blood glucose (p < 0.001). The higher dose (40 mg/kg) of Biochanin A signific...Continue Reading

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Mentioned in this Paper

Glycated Hemoglobin TEST
Diabetes Mellitus, Non-Insulin-Dependent
Study
SIRT1 protein, human
Oral Glucose Tolerance Test
SIRT1
Insulin Sensitivity
Diet
Immunohistochemistry
Homeostatic Model Assessment of Insulin Resistance

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