Biochemical abnormalities in neonatal seizures

Indian Journal of Pediatrics
Arvind SoodRoshan Sharma

Abstract

The presence of seizure does not constitute a diagnoses but it is a symptom of an underlying central nervous system disorder due to systemic or biochemical disturbances. Biochemical disturbances occur frequently in the neonatal seizures either as an underlying cause or as an associated abnormality. In their presence, it is difficult to control seizure and there is a risk of further brain damage. Early recognition and treatment of biochemical disturbances is essential for optimal management and satisfactory long term outcome. The present study was conducted in the department of pediatrics in IGMC Shimla on 59 neonates. Biochemical abnormalities were detected in 29 (49.15%) of cases. Primary metabolic abnormalities occurred in 10(16.94%) cases of neonatal seizures, most common being hypocalcaemia followed by hypoglycemia, other metabolic abnormalities include hypomagnesaemia and hyponateremia. Biochemical abnormalities were seen in 19(38.77%) cases of non metabolic seizure in neonates. Associated metabolic abnormalities were observed more often with Hypoxic-ischemic-encephalopathy (11 out of 19) cases and hypoglycemia was most common in this group. No infant had hyponateremia, hyperkelemia or low zinc level.

References

Dec 1, 1991·Journal of Tropical Pediatrics·K I Airede
Jul 1, 1970·The Journal of Pediatrics·L M DubowitzC Goldberg
Aug 1, 1982·Archives of Disease in Childhood·H J Goldberg, E M Sheehy
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·E RAABO, T C TERKILDSEN

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Citations

Jul 25, 2003·Pediatric Neurology·Seth A KaufmanJ Colin Partridge
Oct 5, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M NdiayeM-M Ndiaye

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