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Biochemical Activity of Vaborbactam

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Ruslan Tsivkovski, Olga Lomovskaya

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Abstract

The most common mechanism of resistance to β-lactams antibiotics in Gram-negative bacteria is production of β-lactamase enzymes capable of cleaving the β-lactam ring. Inhibition of β-lactamase activity with small molecule drugs is a proven strategy to restore the potency of many β-lacta...read more

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Classification
Gram-Negative Bacteria
Monobactams
Recombinant Proteins
Meropenem
Infections, Hospital
Carbapenemase
beta-Lactams
Beta-Lactamase
Research Study
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Biochemical Activity of Vaborbactam

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Ruslan Tsivkovski, Olga Lomovskaya

PMID: 31712199

DOI: 10.1128/aac.01935-19

Abstract

The most common mechanism of resistance to β-lactams antibiotics in Gram-negative bacteria is production of β-lactamase enzymes capable of cleaving the β-lactam ring. Inhibition of β-lactamase activity with small molecule drugs is a proven strategy to restore the potency of many β-lacta...read more

Mentioned in this Paper

Classification
Gram-Negative Bacteria
Monobactams
Recombinant Proteins
Meropenem

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