Biochemical alterations in neonatal hypoxic ischaemic brain damage

Prostaglandins, Leukotrienes, and Essential Fatty Acids
K GücüyenerA Hasanoğlu

Abstract

Asphyxiated (n = 39) and control (n = 23) were elected for the study. Free radical-mediated lipid peroxidation, prostaglandin E2 and vitamin E levels were studied and the degree of hypoxic ischaemic encephalopathy was determined in each case. In the hypoxic group the concentration of prostaglandin E2 activity (P < 0.05) and malondialdehyde levels (P < 0.01) were significantly higher when compared to that of controls. The high vitamin E concentrations in the asphyxiated infants supports the role of oxygen free radicals in hypoxic ischaemic encephalopathy of newborns.

Citations

Nov 21, 1997·Nature·T F Franke, L C Cantley
Nov 21, 1997·Nature·K Hinchliffe, R Irvine

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