Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5

Science
C TerhorstS F Schlossman

Abstract

Two major functionally distinct T cell subsets in man have been defined with heteroantiserums and monoclonal antibodies directed against stable cell surface antigens that appear during thymic ontogeny. A monoclonal antibody to T4 antigen (anti-T4) is reactive with the peripheral inducer T cell population while a monoclonal antibody to T5 antigen (anti-T5) is reactive with the cytotoxic and suppressor population. Immunoprecipitation and electrophoresis on sodium dodecyl sulfate polyacrylamide gel were used to show that on human thymocytes or peripheral T cells the T4 antigen is a single 62,000-dalton glycoprotein while the T5 antigen is a complex of two glycoproteins, one being 30,000 daltons and the other 32,000 daltons. Similar glycoproteins have been isolated with antibodies to murine Lyt 1 and Lyt 2,3 antigens. Both the antigens defining the phenotypes of inducer and suppressor populations in man and mouse are structurally homologous.

References

Jun 20, 1978·Annals of the New York Academy of Sciences·C G Gahmberg, L C Andersson
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H Cantor, E A Boyse
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C TerhorstJ L Strominger
Aug 1, 1976·The Journal of Experimental Medicine·P J Durda, P D Gottlieb
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P CresswellR T Kubo
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman

❮ Previous
Next ❯

Citations

Dec 21, 2005·Rheumatology International·Matthias F SeidelHans Vetter
May 8, 1990·Journal of Immunological Methods·P PortolésC A Janeway
Jan 1, 1984·Developmental and Comparative Immunology·G W WarrD P Anderson
Jan 1, 1983·Pharmacology & Therapeutics·W E Magee, S S Ristow
Jul 1, 1994·Veterinary Immunology and Immunopathology·J KyddM A Holmes
Aug 1, 1981·Cancer Genetics and Cytogenetics·J SchröderK Autio
Jan 1, 1981·International Journal of Immunopharmacology·T CotnerJ L Strominger
Apr 29, 1982·Biochimica Et Biophysica Acta·C G Gahmberg, L C Andersson
Jun 1, 1989·Research in Immunology·S CarrelJ C Cerottini
Mar 31, 1998·Journal of Immunological Methods·M FerrerM R van Schravendijk
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C D Platsoucas, R A Good
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J LeonardW C Greene
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D KozborC M Croce
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S J ClarkA F Williams
Jun 1, 1982·The Journal of Cell Biology·V T OiL Stryer
Sep 1, 1983·The Journal of Experimental Medicine·J FujimotoR Levy
Jan 1, 1989·The Journal of Experimental Medicine·D R LuceyP F Weller
Aug 19, 2000·Psychosomatic Medicine·D A GrangerD R Johnson
Feb 1, 1983·American Journal of Ophthalmology·D M Knowles, F A Jakobiec
Dec 13, 2000·Journal of Molecular and Cellular Cardiology·W Lewis
Feb 20, 2010·International Journal of Pediatrics·Emmanuel Oni IdigbeSylvester U Ikondu
Jul 1, 1984·The Journal of Experimental Medicine·J FujimotoR Levy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.