PMID: 2510934Nov 17, 1989Paper

Biochemical analysis of transcriptional activation by Jun: differential activity of c- and v-Jun

Cell
D Bohmann, R Tjian

Abstract

The human proto-oncogene product, c-Jun, is a member of the AP-1 family of transcription factors, which mediate the regulation of gene expression in response to extracellular signaling. Comparison of c-Jun and v-Jun by in vitro transcription assays revealed that v-Jun has significantly greater transcriptional activity than c-Jun. Analysis of Jun mutants expressed in bacteria indicates that this difference in transcriptional activity is due to the presence of a regulatory domain located at the N-terminal region of c-Jun. Other Jun mutants identify an activation domain rich in acidic and proline residues toward the C-terminal end of the molecule, in a region near the DNA binding domain. These findings suggest that during retroviral transduction, a constitutively active Jun protein has been generated by deleting a negatively acting domain. This putative repressor domain may also play a role in the signal-dependent induction of c-Jun activity.

References

Dec 1, 1988·Genes & Development·F J RauscherT Curran
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J SchütteM J Birrer
Apr 11, 1988·Nucleic Acids Research·J L ImlerB Wasylyk
Jan 1, 1988·Cold Spring Harbor Symposia on Quantitative Biology·A R BallP K Vogt
Jan 27, 1989·Science·E K O'SheaP S Kim
Dec 15, 1988·Nature·T Kouzarides, E Ziff
Oct 20, 1988·Nature·M Ptashne
May 20, 1988·Science·F J RauscherB R Franza
Nov 4, 1988·Cell·T Curran, B R Franza
Jan 1, 1988·Cold Spring Harbor Symposia on Quantitative Biology·D BohmannR Tjian
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K RyderD Nathans
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J T Kadonaga, R Tjian
May 5, 1986·Journal of Molecular Biology·F W Studier, B A Moffatt
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T A Kunkel

❮ Previous
Next ❯

Citations

Sep 13, 1996·Journal of Immunological Methods·P I NeophytouJ C Hutton
Dec 10, 1991·Biochimica Et Biophysica Acta·C V Dang
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Dec 16, 1992·Biochimica Et Biophysica Acta·S E PlyteJ R Woodgett
Jun 1, 1991·Current Opinion in Cell Biology·J Ghysdael, M Yaniv
Mar 1, 1997·Brain Research. Molecular Brain Research·R Herbst, M J Nicklin
Sep 22, 2001·The Journal of Steroid Biochemistry and Molecular Biology·S MaruyamaA Ito
Nov 9, 2002·Immunology·Bing-Hung ChenDaniel H Conrad
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S G ShoemakerK Kaushansky
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T S HuangJ K Lin
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K SchillingT Curran
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J OurslerT C Spelsberg
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A SwaroopN Agarwal
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·V AdlerA S Kraft
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C C FranklinA S Kraft
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Deng, M Karin
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L S HåvarsteinP K Vogt
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A G PapavassiliouD Bohmann
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D JonesJ K Tillotson
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F S Monteclaro, P K Vogt
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J C CrossW J Rutter
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·V DoucasA Dejean
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T KamedaH Iba
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·T S SchaeferD Nathans
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·P I NeophytouJ C Hutton
Nov 1, 1995·The Journal of Cell Biology·L J Page, M S Robinson
Oct 11, 1992·Molecular Biology of the Cell·S Y ChouJ E Ferrell
Dec 22, 2006·Molecular Biology of the Cell·Kongming WuRichard G Pestell
Dec 11, 1994·Nucleic Acids Research·A J BannisterT Kouzarides
Jun 1, 1993·Antimicrobial Agents and Chemotherapy·S MartinT A Springer
Feb 7, 2007·Molecular and Cellular Biology·Benoit GrondinTrang Hoang
Aug 31, 2011·Molecular and Cellular Biology·Wei WeiYihong Wan
Jun 8, 2001·Molecular and Cellular Biology·S LeppäD Bohmann
Jun 8, 2002·Molecular and Cellular Biology·Latifa BakiriMoshe Yaniv
Sep 1, 1997·The Journal of Clinical Investigation·H BöhrerP P Nawroth

❮ Previous
Next ❯

Related Concepts

Related Feeds

BioHub - Researcher Network

The Chan-Zuckerberg Biohub aims to support the fundamental research and develop the technologies that will enable physicians to cure, prevent, or manage all diseases in our childrens' lifetimes. The CZ Biohub brings together researchers from UC Berkeley, Stanford, and UCSF. Find the latest research from the CZ Biohub researcher network here.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.