Biochemical and antigenic characterization of the Mycobacterium tuberculosis 71kD antigen, a member of the 70kD heat-shock protein family

Molecular Microbiology
A Mehlert, D B Young

Abstract

A 71 kiloDalton antigen from Mycobacterium tuberculosis is recognized by antibodies and by T lymphocytes during infection (Britton et al., 1986a). Partial sequence analysis indicates a relationship between this antigen and the highly conserved family of 70-kiloDalton heat shock proteins (hsp70) (Young et al., 1988). Biochemical and serological characterization of the protein confirms its membership of the hsp70 gene family, and metabolic labelling demonstrates that it is a major component of the mycobacterial response to heat stress. The role of stress proteins as antigens during infection is discussed.

References

Jun 1, 1988·Molecular and Biochemical Parasitology·R HedstromG Newport
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A YoungR W Davis
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A E BiancoD J Kemp
May 1, 1987·The Journal of Experimental Medicine·R HedstromG Newport
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D YoungR A Young
Jun 1, 1988·Annals of the Rheumatic Diseases·E BeccericaG Ferretti
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R W MorganB N Ames
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H K MitchellC H Buzin
Jun 21, 1985·Science·L H Van der PloegC R Cantor

❮ Previous
Next ❯

Citations

Jan 1, 1991·Research in Microbiology·D B Young, T R Garbe
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D EliasI R Cohen
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A HorwitzG Harth
May 15, 1994·European Journal of Biochemistry·E RománD Young
Oct 24, 2003·Infection and Immunity·Rakesh Kumar ChoudharySeyed E Hasnain
Nov 30, 1994·Experientia·G Del Giudice
Sep 9, 1999·Molecular Plant-microbe Interactions : MPMI·L M KeithC L Bender
Jul 3, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Thiago J BorgesCristina Bonorino
Jun 1, 1991·Immunological Reviews·P M LydyardM Smith
Jul 1, 1993·Scandinavian Journal of Immunology·E M NualláinD J Reen
Dec 1, 1990·Bioscience Reports·G M AlderC A Pasternak
Nov 25, 2014·PloS One·Rafael L LopesCristina Bonorino
Oct 12, 2010·Tuberculosis·Frederic VanzemberghMichael Kalai
Jun 26, 2012·Clinics in Laboratory Medicine·Camilla Rodrigues, Viral Vadwai
Oct 1, 1991·European Journal of Immunology·A R LussowG Del Giudice
Apr 1, 1993·Journal of Clinical Pathology·K Y YuenM H Ng
Aug 1, 1992·Clinical and Experimental Immunology·A ElsaghierJ Ivanyi
Mar 7, 2017·Frontiers in Cellular and Infection Microbiology·Saurabh PandeySeyed E Hasnain
Aug 30, 2018·Nature Communications·Thiago J BorgesCristina Bonorino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.