Abstract
Aberrant differentiation is a frequent hallmark of tumors, suggesting that modulators for differentiation and proliferation play a role in multistage carcinogenesis and that their use can also be exploited in cancer chemoprevention and therapy. We have demonstrated that selenium (Se) may be a modulator for the differentiation and proliferation of tumor cells. Evidence has been obtained that Se exerts the following effects: reversing changes of biochemical phenotypes toward normal levels, including reduction of cGMP level and cAMP-dependent protein kinase isozyme type I; increase in cAMP level and cAMP-dependent protein kinase isozyme type II, and altering membrane properties. Furthermore, we have obtained support for this hypothesis utilizing experiments on cultured human liver cell lines. It is demonstrated that Se can lead to the following changes: a. reduction of mitotic index; b. increase in the adhesiveness of cells; c. decrease in confluent saturation density and induction of an early contact inhibition; and d. decrease in tumorigenicity. For the purpose of comparison, the effects of Se on the normal counterparts was also studied. Contrary to what was observed above, there was no significant change in both biochemical and...Continue Reading
References
Apr 1, 1978·Physiology & Behavior·L B MarshallO A Smith
Nov 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M InbarG Mathé
May 4, 1978·Biochimica Et Biophysica Acta·S W de LaatM Shinitzky
May 1, 1978·Progress in Cardiovascular Diseases·R E Kerber, M L Marcus
Sep 8, 1975·Journal of Molecular Evolution·J GresselN Cohen
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Jan 1, 1984·Biochimica Et Biophysica Acta·M Shinitzky
Aug 1, 1980·Journal of Bioenergetics and Biomembranes·S J Karlish
Citations
Jan 1, 1997·Biological Trace Element Research·S Y YuW G Li
Jan 1, 1988·Biological Trace Element Research·J Clausen, S A Nielsen
Jun 1, 1991·Biological Trace Element Research·S Y YuC Hou
Mar 30, 2011·Chemical Research in Toxicology·Xiaodan LiuShana J Sturla
Oct 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·J L BurgueraM Gallignani
Aug 1, 1993·Medical Hypotheses·R S BedwalR S Mathur
Jul 31, 1992·Cancer Letters·F I AbdullaevG D Frenkel
Aug 5, 2003·The Journal of Biological Chemistry·Yu-Chi LeeAnn-Ping Tsou
Nov 13, 2001·Oncogene·L Degos, Z Y Wang
Sep 19, 2012·Autism : the International Journal of Research and Practice·Ervin PoljacJohan Wagemans
Sep 4, 2019·Nature Communications·Ainhoa ArinaRalph R Weichselbaum
Aug 1, 1997·Cognitive Neuropsychiatry·M Annett
Apr 5, 2003·Der Internist·R MückeO Micke
Apr 1, 1992·Biological Trace Element Research·G N Schrauzer