PMID: 7024126Jun 1, 1981Paper

Biochemical and cellular reaction of PVS paste polymers and latex following intratracheal instillation into rats

Inflammation
T D TetleyR J Richards

Abstract

Rats were given different doses (0.25-25 mg) of two forms of PVC past polymers and polystyrene by intratracheal instillation and monitored for cellular and biochemical changes in the lung lavage fluid and remaining lung tissue after 1 and 4 weeks of exposure. Changes were observed in free cell morphology, the level of pulmonary surfactant, and hydrolytic enzyme activities with all three compounds at high concentrations. Some differences in the extent of changes produced per given mass identified were noted with different formulations and the relationship between particle numbers, surface areas, and detergent coatings of samples is discussed. It is argued that PVC paste polymers and polystyrene cannot be considered totally biologically inert but that, in comparison with active cytoxic and inflammatory minerals such as chrysotile asbestos, the extent of their initial reaction in the lung is relatively weak.

References

Jan 1, 1979·The Annals of Occupational Hygiene·G H Pigott, J Ishmael
Jan 31, 1975·Annals of the New York Academy of Sciences·A MillerR Warshaw
Aug 21, 1975·Nature·R J RichardsF A Rose
Mar 4, 1976·Nature·R J RichardsF A Rose
Dec 1, 1981·Environmental Research·R J RichardsJ Hunt

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Citations

May 19, 1998·Life Sciences·S A MurphyR J Richards
Jan 1, 1995·Mediators of Inflammation·S F SmithT D Tetley

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