Biochemical and clinical benefits of unilateral adrenalectomy in patients with subclinical hypercortisolism and bilateral adrenal incidentalomas

European Journal of Endocrinology
I PerogamvrosStylianos Tsagarakis

Abstract

The treatment of subclinical hypercortisolism in patients with bilateral adrenal incidentalomas (AI) is debatable. We aimed to compare the biochemical and clinical outcome of unilateral adrenalectomy vs a conservative approach in these patients. Retrospective study. The study included 33 patients with bilateral AI; 14 patients underwent unilateral adrenalectomy of the largest lesion (surgical group), whereas 19 patients were followed up (follow-up group). At baseline and at each follow-up visit, we measured 0800 h plasma ACTH, midnight serum cortisol (MSF), 24-h urinary-free cortisol (UFC) and serum cortisol following a standard 2-day low-dose-dexamethasone-suppression test (LDDST). We evaluated the following comorbidities: arterial hypertension, impaired glucose tolerance or diabetes mellitus, dyslipidemia and osteoporosis. Baseline demographic, clinical characteristics and the duration of follow-up (53.9±21.3 vs 51.8±20.1 months, for the surgical vs the follow-up group) were similar between groups. At the last follow-up visit the surgical group had a significant reduction in post-LDDST cortisol (2.4±1.6 vs 6.7±3.9 μg/dl, P=0.002), MSF (4.3±2 vs 8.8±4.6 μg/dl, P=0.006) and 24-h UFC (50.1±21.1 vs 117.9±42.4 μg/24 h, P=0.0007) a...Continue Reading

References

Aug 1, 1995·Endocrine Reviews·R T KloosB Shapiro
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jun 24, 2006·Journal of Endocrinological Investigation·S TsagarakisN Thalassinos
Jan 25, 2008·World Journal of Surgery·Maurizio IacoboneGennaro Favia
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Iacopo ChiodiniAlfredo Scillitani
Jun 29, 2011·Nature Reviews. Endocrinology·Dimitra A Vassiliadi, Stylianos Tsagarakis
Oct 13, 2011·Clinical Endocrinology·M TerzoloG Reimondo
Nov 22, 2012·European Journal of Endocrinology·V MorelliI Chiodini
Jun 19, 2014·Polskie Archiwum Medycyny Wewnętrznej·Lucyna PapierskaAnna Kasperlik-Załuska

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Citations

Sep 14, 2016·Maturitas·Stavroula A PaschouDimitrios G Goulis
Feb 1, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Luigi PetramalaClaudio Letizia
Sep 29, 2018·The Journal of Clinical Endocrinology and Metabolism·Henrik OlsenOla Lindgren
Oct 12, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Gamze AkkusTamer Tetiker
Jun 18, 2019·Clinical Pharmacology and Therapeutics·Danae A DelivanisIrina Bancos
Mar 27, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Dimitra A VassiliadiStylianos Tsagarakis
Mar 16, 2018·Journal of Endocrinological Investigation·C T BahadirH Atmaca
May 12, 2018·European Journal of Endocrinology·Isabelle BourdeauAndré Lacroix
Apr 9, 2020·Endocrine Reviews·Mark SherlockPaul M Stewart
Oct 15, 2020·JAMA Surgery·Barbra S Miller, Richard J Auchus
Feb 28, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Léamarie Meloche-DumasAndré Lacroix
Aug 14, 2020·Current Pharmaceutical Design·Miomira IvovićSvetlana Vujović

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