PMID: 2484393Apr 1, 1989Paper

Biochemical and clinical effects of an antioxidative supplementation of geriatric patients. A double blind study

Biological Trace Element Research
J ClausenM Kristensen

Abstract

Ninety seven geriatric patients from two Danish homes for old people accepted to participate in a blinded experiment designed to counteract ageing phenomena. The subjects were split into two groups, i.e., the verum and the placebo group. The verum group received daily for one year an antioxidative cocktail consisting of: 300 micrograms selenium as L-selenomethionine, 45 mg zinc, 270 mg vitamin C, 2.7 mg vitamin A, 6 mg vitamin B-6, and 465 mg vitamin E (d-alfatocopherol). Furthermore, in order to enhance exchange in polyenoic acids, each subject received daily 250 mg gamma-linolenic acid. The placebo groups received similar looking pills and capsules without the active components. During one year in the verum group, the whole blood selenium, the hydrogen-dependent glutathione peroxidase (GSH-Px) of erythrocytes, and the vitamin E level in serum was found increased compared to the pretreatment values and to the placebo group. No change could be traced in the t-butylhydroperoxide dependent GSH-Px, an enzyme that also assays the glutathione-s-transferase. During the same period of time, the fasting levels of serum fatty acids and the content of lipofuscin in erythrocytes were estimated. Compared to the pretreatment values, the lip...Continue Reading

References

Jun 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·G E JensenJ Clausen
Aug 23, 1976·Biochemical and Biophysical Research Communications·R A Lawrence, R F Burk
Jul 1, 1975·Acta Physiologica Scandinavica·L KanervaA H Tissari
Jan 1, 1988·Biological Trace Element Research·J ClausenS A Nielsen
Jan 1, 1986·Progress in Brain Research·R S Sohal, L S Wolfe
Oct 1, 1971·Journal of Neuropathology and Experimental Neurology·J A FerrendelliV Suntzeff
Apr 1, 1973·Lipids·W R Bidlack, A L Tappel
Nov 1, 1984·Acta Neurologica Scandinavica·J Clausen
Oct 1, 1983·Scandinavian Journal of Clinical and Laboratory Investigation·K JaakkolaA U Arstila
Jan 1, 1984·Contributions to Nephrology·J Savory, M R Wills
Jan 1, 1984·Annals of Nutrition & Metabolism·M WartanowiczG Okolska
Jan 1, 1982·Gerontology·C G GottfriesG Steen

❮ Previous
Next ❯

Citations

Jan 1, 1991·Biological Trace Element Research·J Clausen
Jun 1, 1991·Biological Psychiatry·D Benton, R Cook
Jan 1, 1991·Free Radical Biology & Medicine·W A Pryor, S S Godber
Jun 2, 2005·Progress in Neurobiology·Eugenio MocchegianiMarco Malavolta
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Leticia F PettenuzzoMoacir Wajner
Jul 27, 2001·Brain Research Bulletin·E MocchegianiP Zatta
May 12, 2001·The British Journal of Nutrition·G F Combs
Jul 1, 1994·The Proceedings of the Nutrition Society·P H Evans
Jun 14, 2003·Journal of the American College of Nutrition·Wendeline Wouters-WesselingWija A van Staveren
Aug 21, 2013·Critical Reviews in Food Science and Nutrition·Rachel HurstSusan J Fairweather-Tait
Apr 9, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Wendeline Wouters-WesselingWija A van Staveren
Jan 31, 2008·Journal of Clinical Biochemistry and Nutrition·Kei OhwadaShiro Urano
Nov 21, 2009·Journal of Nutritional Science and Vitaminology·Hirokatsu TakatsuShiro Urano
May 1, 1996·International Journal of Food Sciences and Nutrition·I F Benzie
Jan 6, 2004·Free Radical Research·Amanpreet SinghShrinivas K Kulkarni
Sep 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·Z L Hegedus, U Nayak
Jun 30, 1994·Annals of the New York Academy of Sciences·F SchneiderR Mateescu
Oct 16, 2015·Brain Research·Iraj SalehiAbdolrahman Sarihi
Jun 28, 2005·Journal of Pineal Research·Giyasettin BaydasAbdullah Yasar
Mar 16, 2012·BioFactors·Claudine BerrTasnime N Akbaraly
Jan 15, 1996·Biological Psychiatry·W C Hawkes, L Hornbostel
Jan 1, 1994·Archives of Gerontology and Geriatrics·R PopaR Mateescu
Jan 2, 2003·Nutritional Neuroscience·David Benton
Apr 22, 2015·Critical Reviews in Food Science and Nutrition·Jorge Moreda-PiñeiroPilar Bermejo-Barrera
Jan 1, 1999·Nutritional Neuroscience·A P SmithK Perry
Feb 7, 2004·International Journal of Hygiene and Environmental Health·Michael LacourGuido Schwarzer
Jul 19, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Oct 21, 2004·The Cochrane Database of Systematic Reviews·L HooperS B J Ebrahim
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Mar 3, 2020·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Jun 30, 1994·Annals of the New York Academy of Sciences·V PredescuL Botezat-Antonescu
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Jennifer R Evans, John G Lawrenson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.