PMID: 2953698Jan 1, 1987

Biochemical and cytochemical comparison of intestinal bicarbonate-stimulated Mg2+ dependent ATPase and alkaline phosphatase activities in rat, rabbit and guinea pig

The Histochemical Journal
I HamdiT J Peters


Bicarbonate-stimulated Mg2+ dependent ATPase activity was demonstrated both biochemically and cytochemically, in brush border membranes from rat, rabbit and guinea pig duodenum. There was no correlation between enzyme activity and basal HCO3- secretion rates in the different species. The concentration of HCO3- necessary for optimal stimulation of ATPase activity, degree of stimulation and total activity was higher in the rat than in other species. Activity was higher in rat duodenum than in the ileum. This is consistent with the proposed electrogenic HCO3- secretion in the duodenum. Distribution of activities of alkaline phosphatase and HCO3(-)-stimulated Mg2+-ATPase along the duodenal villus showed significant differences, suggesting that the two activities reflect, at least in part, distinct enzymes.


Dec 1, 1975·The American Journal of Physiology·R G Fiddian-Green, W Silen
Nov 1, 1977·Analytical Biochemistry·J Kapuściński, B Skoczylas
Jan 1, 1979·The American Journal of Physiology·G RieserG Inesi
Feb 1, 1973·Analytical Biochemistry·G R Schacterle, R L Pollack
Dec 1, 1967·The American Journal of Physiology·K A Hubel
Aug 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·V S ShubinV G Ter-Simonian


Dec 17, 2003·Journal of Gastroenterology and Hepatology·Yutaka KonnoTooru Shimosegawa
Jun 9, 2009·Journal of Medical Microbiology·Niall T StevensHilary Humphreys
Oct 6, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasutada AkibaJonathan D Kaunitz

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