PMID: 16629151Apr 25, 2006Paper

Biochemical and histopathological effects in pearl dace (Margariscus margarita) chronically exposed to a synthetic estrogen in a whole lake experiment

Environmental Toxicology and Chemistry
V P PalaceK A Kidd

Abstract

Potential effects of exposure to the synthetic estrogen 17alpha-ethynylestradiol (EE2) were examined in several species of fish from a lake experimentally treated with environmentally relevant concentrations of the contaminant. Ethynylestradiol was added to Lake 260, a small Precambrian shield lake at the Experimental Lakes Area in northwestern Ontario, Canada, from May to October of 2001, 2002, and 2003. Mean concentrations of EE2 in epilimnetic waters ranged between 4.5 and 8.1 ng/L during the three years, with overall means of 6.1 (+/- 2.8), 5.0 (+/- 1.8), and 4.8 (+/- 1.0) ng/L for the three years, respectively. Male and female pearl dace (Margariscus margarita) captured after EE2 additions began contained up to 4,000-fold higher concentrations of the egg yolk precursor vitellogenin than fish captured from the same lake before the EE2 additions or when compared to fish from reference lakes. Edema in the ovaries, inhibited development of testicular tissue, intersex, and histopathological kidney lesions were all evident in fish exposed to EE2. Some indications that EE2 exposure affected in vitro steroidogenic capacity of the ovaries and the testes existed, although results were not always consistent between years. Pearl dace ...Continue Reading

Citations

Mar 7, 2008·Archives of Environmental Contamination and Toxicology·Ken M JeffriesKelly R Munkittrick
Mar 3, 2011·Environmental Health Perspectives·Catherine A HarrisJohn P Sumpter
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karen A KiddRobert W Flick
Jun 30, 2014·Archives of Environmental Contamination and Toxicology·Beth H BakerHeiko L Schoenfuss
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karen A KiddKarsten Liber
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tomas BrodinMicael Jonsson
Aug 17, 2010·Hormones and Behavior·Charlyn PartridgeAdam G Jones
Jun 24, 2015·Ecotoxicology and Environmental Safety·A L OropesaM C Gil
Mar 20, 2008·Fertility and Sterility·Louis J Guillette, Thea M Edwards
Jan 22, 2008·Ecotoxicology and Environmental Safety·Jinmiao ZhaZijian Wang
Feb 12, 2011·Environmental Toxicology and Chemistry·Gerty J H P GielenLaurie G Greenfield
Jul 28, 2015·Journal of Applied Toxicology : JAT·Ahmed Abdel-MoneimMaria S Sepúlveda
Dec 28, 2016·Environmental Science & Technology·Keegan A HicksMark R Servos
Aug 19, 2007·Biology of Reproduction·Richard J MaunderTom G Pottinger
Jul 16, 2008·Environmental Toxicology and Chemistry·Eve B DussaultPaul K Sibley
Jul 22, 2020·Environmental Toxicology and Chemistry·Karen A KiddCheryl L Podemski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.