PMID: 6985648Jan 1, 1980Paper

Biochemical and immunological characterization of the extracellular nucleases of group B streptococci

The Journal of Experimental Medicine
P FerrieriL W Wannamaker

Abstract

Nearly all group B streptococcal strains representing the five major serotypes were found to produce extracellular nucleases by screening with an agar-well-diffusion technique in DNA-methyl green agar plates. Three different nucleases have been isolated and partially purified by DEAE-and carboxymethyl-cellulose chromatography. They possessed different mobilities on polyacrylamide gel electrophoresis and different molecular weights. These nucleases, designated I, II, and III, are optimally activated by cations of calcium and manganese and exhibited RNase as well as DNase activity. Despite differences in their physical and biochemical properties, nucleases II and III appear antigenically similar, but distinct from nuclease I. These group B streptococcal nucleases are immunologically different from the nucleases of group A streptococci. Neutralizing activity, probably antibody, to nucleases II and III was found in human sera, and was most prevalent in sera of pregnant women colonized with group B streptococci and in their newborn infants.

References

Feb 1, 1976·The Journal of Experimental Medicine·C J BakerC E Davis
Feb 1, 1977·Journal of Medical Microbiology·P FerrieriA E Seeds
Jan 1, 1977·Annual Review of Medicine·B F Anthony, D M Okada
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Jan 1, 1970·The New England Journal of Medicine·L W Wannamaker
Jul 1, 1968·Archives of Biochemistry and Biophysics·J L Hedrick, A J Smith

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Citations

Jan 1, 1990·Journal of Basic Microbiology·B B Griffiths
Jan 27, 2004·Infection and Immunity·Michael C FontainePhilip J Willson
Feb 4, 2014·Nature Medicine·Frank J HernandezJames O McNamara
Dec 1, 1992·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·B T FerreiraL Barrucand
Jun 1, 2005·Microbial Pathogenesis·Carey-Ann D BurnhamGregory J Tyrrell
Nov 18, 2003·Molecular Microbiology·Karen M Puopolo, Lawrence C Madoff
Oct 1, 1983·Journal of Clinical Microbiology·A E Flores, P Ferrieri
Sep 1, 1980·Journal of Clinical Microbiology·D C StrausT J Nealon
Dec 1, 1981·Infection and Immunity·B A Marchlewicz, J L Duncan
Dec 1, 1980·Infection and Immunity·B A Marchlewicz, J L Duncan
Jun 21, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Inês SilvestreMaria José Borrego

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