Biochemical and immunological responses of young turkeys to vaccination against Ornithobacterium rhinotraheale and different levels of dietary methionine

Polish Journal of Veterinary Sciences
M KubińskaJ Jankowski

Abstract

The objective of this study was to verify the hypothesis that increasing levels of dietary methionine can stimulate the mechanisms of cell-mediated and humoral immunity in young turkeys. The blood and organs involved in cell-mediated and humoral immune responses were analyzed in 8-week-old turkeys that had been vaccinated against Ornithobacterium rhinotraheale (ORT) infection (on days 17 and 48). The birds were fed diets with a low (LM), medium (MM) and high (HM) methionine content (0.45 and 0.40%, 0.60 and 0.51%, 0.71 and 0.57% in weeks 1 - 4 and 5 - 8, respectively). Dietary methionine supplementation led to a significant increase in body weights of turkeys at 56 days of age, from 3532 g in group LM to 3720 g in group MM and 3760 g in group HM (p=0.001). A significant increase in vaccine-induced antibody titers against ORT was noted in group HM relative to group LM (p=0.006). Increasing levels of methionine had no significant effect on total serum IgG nor IgM levels and most serum biochemical parameters, TP, ALB, GLOB, GLU, AST, ALP, P and Ca. In comparison with group LM, group HM turkeys were characterized by a lower percentage of IgM⁺ B cell subpopulation in the blood and bursa of Fabricius. The percentages of CD4⁺ and CD8⁺...Continue Reading

References

Sep 1, 1988·The Journal of Nutrition·K C Klasing, D M Barnes
Nov 14, 2007·Clinical Pharmacology and Therapeutics·G C Gray, W S Baker
Jul 6, 2014·Polish Journal of Veterinary Sciences·B TykałowskiA Koncicki
Feb 3, 2015·Polish Journal of Veterinary Sciences·M KubińskaA Koncicki

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Citations

Aug 21, 2020·Journal of Animal Physiology and Animal Nutrition·Katarzyna OgnikJan Jankowski

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