Biochemical and Molecular Alterations Following Arsenic-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Brain

Biological Trace Element Research
Chandra PrakashVijay Kumar

Abstract

Oxidative stress is associated with the generation of reactive oxygen species (ROS), which is supposed to be one of the mechanisms of arsenic-induced neurodegeneration. Mitochondria, being the major source of ROS generation may present an important target of arsenic-mediated neurotoxicity. Hence, we planned the study to elucidate the possible biochemical and molecular alterations induced by arsenic exposure in rat brain mitochondria. Chronic sodium arsenite treatment (25 ppm for 12 weeks) resulted in decreased activity of mitochondrial complexes I, II, and IV followed by increased ROS generation. There was decrease in mitochondrial superoxide dismutase (MnSOD) activity in arsenic-treated rat brain further showing increased superoxide radical generation in mitochondria. The decrease in MnSOD activity might be responsible for the increased protein and lipid oxidation as observed in our study. Protein and messenger RNA (mRNA) levels of MnSOD and mitochondrial uncoupling protein 2 (UCP-2) were downregulated suggesting decreased removal of ROS in rat brain. Fourier transform infrared (FTIR) spectroscopy analysis revealed significant decrease in amide A, amide I, amide II, and Olefinic = CH stretching band area suggesting molecular a...Continue Reading

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Citations

Oct 30, 2015·Journal of Applied Toxicology : JAT·Chandra PrakashVijay Kumar
Jan 16, 2016·Biological Trace Element Research·Chandra Prakash, Vijay Kumar
Jul 24, 2015·Journal of Pineal Research·Anna FernándezJosé L Mauriz
Nov 9, 2016·Neurotoxicology·Djai B Heyer, Rhiannon M Meredith
Feb 23, 2017·Journal of Biochemical and Molecular Toxicology·Manisha SoniVijay Kumar
Nov 15, 2015·The Journal of Experimental Biology·Ensiyeh Ghanizadeh KazerouniFrank Seebacher
Mar 3, 2018·Applied Biochemistry and Biotechnology·Manisha SoniVijay Kumar
Nov 22, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Carla Garza-LombóRodrigo Franco
Aug 20, 2019·Metabolic Brain Disease·Soheila AlboghobeishMohsen Rezaei
Mar 15, 2018·Current Environmental Health Reports·Kylie D Rock, Heather B Patisaul
Jul 6, 2020·Nature Communications·Sunyuan ZhangMarie A Bogoyevitch
Jun 24, 2020·Journal of Hazardous Materials·Afsane BahramiAmirhossein Sahebkar
Apr 19, 2021·Biological Trace Element Research·Farzan MozaffarianMasoud Mahdavinia
May 6, 2021·Molecular Biology Reports·Elif OguzSaniye Ada

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