Biochemical and Molecular Mechanisms of Radioprotective Effects of Naringenin, a Phytochemical from Citrus Fruits

Journal of Agricultural and Food Chemistry
Sumit Kumar, Ashu Bhan Tiku

Abstract

The present study was aimed to evaluate the radioprotective effects of naringenin in vivo using Swiss albino mice as a model system. Oral administration of 50 mg/kg body weight of naringenin for 7 days prior to radiation exposure protected mice against radiation-induced DNA, chromosomal and membrane damage. Naringenin pretreatment also increased the antioxidant status of irradiated mice. Multiple factors operating at cellular and molecular levels led to increased endogenous spleen colonies and survival of mice. Although naringenin induces apoptosis in cancer cells we found that it can protect against radiation-induced apoptosis in normal cells by modulating the expression of p53, Bax, and Bcl-2. The results from the present study indicate that naringenin inhibits the NF-kB pathway and down regulates radiation-induced apoptotic proteins resulting in radioprotection at the cellular, tissue and organism levels.

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Citations

Sep 25, 2019·Archives of Pharmacal Research·Xinyan QuZhe Zhou
Apr 24, 2020·Journal of Analytical Methods in Chemistry·Dan XuChen Ma
Jan 13, 2019·Pharmaceuticals·Bahare SalehiJavad Sharifi-Rad
Dec 20, 2019·Journal of Bioenergetics and Biomembranes·Soghra FarzipourSeyed Jalal Hosseinimehr
Oct 28, 2020·Antioxidants·Tsu-Kung LinYao-Chung Chuang
Aug 27, 2019·DNA Repair·Maryam MajidiniaBahman Yousefi
Nov 5, 2020·Biomedicines·Elena ObradorAlegría Montoro
Feb 20, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Adam HermawanHaruma Anggraini Muflikhasari

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