PMID: 9546577Apr 18, 1998Paper

Biochemical and molecular mechanisms regulating apoptosis

Molecular and Cellular Biochemistry
K S Saini, N I Walker

Abstract

In eukaryotes, the regulation of tissue cell numbers is a critical homeostatic objective that is achieved through tight control of apoptosis, mitosis and differentiation. While much is known about the genetic regulation of cell growth and differentiation, the molecular basis of apoptosis is less well understood. Genes involved in both cell proliferation and apoptosis reflect the role of some stimuli in both of these processes, the cell response depending on the overall cellular milieu. Recent research has given fascinating insights into the complex genetic and molecular mechanisms regulating apoptosis. A picture is emerging of the initiation in certain cells, after an apoptotic trigger, of sequential gene expression and specific signal transduction cascades that guide cells along the cell death pathway. Changes in gene expression precede the better known biochemical and morphological changes of apoptosis. It seems possible that, as a result of increased understanding of the cellular events preceding cell death, apoptosis may become more amenable to manipulation by appropriate drug- and gene-based therapies.

Citations

Apr 13, 2000·International Journal of Cancer. Journal International Du Cancer·J KleeffM Korc
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Suhnrita ChaudhuriSwapna Chaudhuri
Aug 17, 1999·Annual Review of Nutrition·M LipkinS A Lamprecht
Jun 18, 2005·World Journal of Gastroenterology : WJG·Qiu-Liang WuLi-Wu Fu
May 17, 2006·Apoptosis : an International Journal on Programmed Cell Death·Luis Francisco Zirnberger BatistaCarlos Frederico Martins Menck
Nov 21, 2009·Bioscience Reports·Manjula Vinayak, Chandramani Pathak
Apr 23, 2002·Glia·Patrizia Di IorioMichel P Rathbone
Aug 3, 2004·Microscopy Research and Technique·Luigi AbbroLuciana Dini
Sep 29, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Vladimir LeskovacJulijan Kandrac
Jan 9, 2004·Journal of Toxicology and Environmental Health. Part a·Rebecca L Uzarski, James J Pestka
Nov 15, 2011·Apoptosis : an International Journal on Programmed Cell Death·Shi-Yang LiYong-Yuan Guan
Jul 17, 1999·Brain Research. Molecular Brain Research·W PeissnerF Gillardon
Apr 13, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H H BackusG J Peters

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis