PMID: 6538546Mar 1, 1984Paper

Biochemical and morphological alterations of baboon hepatic mitochondria after chronic ethanol consumption

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M AraiC S Lieber

Abstract

Baboons fed ethanol (50% of total calories) chronically develop ultrastructural alterations of hepatic mitochondria. To determine whether mitochondrial functions are also altered, mitochondria were isolated from nine baboons fed ethanol chronically and their pair-fed controls. At the fatty liver stage, ADP-stimulated respiration was depressed in ethanol-fed baboons by 59.4% with glutamate, 43.2% with acetaldehyde, 45.1% with succinate and 51.1% with ascorbate as substrates. A similar decrease was noted in the ADP/O ratio (14 to 28%) and respiratory control ratio (20 to 44%) with all substrates. Similar alterations of mitochondrial functions were observed in baboons with more advanced stages of liver disease, namely fibrosis. These changes after ethanol treatment were associated with decreases in the enzyme activities of mitochondrial respiratory chain: glutamate, NADH and succinate dehydrogenase (42, 24 and 28%, respectively), glutamate-, NADH- or succinate-cytochrome c reductase (42, 27 and 32%, respectively) and cytochrome oxidase (59.6%). The content of all cytochromes was also decreased in ethanol-fed baboons, especially aa3 (57%). Moreover, [14C]leucine incorporation into mitochondrial membranes was depressed by 21% after ...Continue Reading

References

Nov 15, 1979·Analytical Biochemistry·C F CesaroneL Santi
Jul 1, 1978·Alcoholism, Clinical and Experimental Research·J D Bernstein, R Penniall
Apr 1, 1979·Archives of Biochemistry and Biophysics·A I Cederbaum, E Dicker
Sep 1, 1977·The Journal of Clinical Investigation·E BaraonaC S Lieber
Jan 1, 1978·Biochemical Pharmacology·J D Bernstein, R Penniall
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C S LieberE Rubin
Dec 1, 1973·The Biochemical Journal·S O TottmarK H Kiessling
Jan 1, 1974·Journal of Medical Primatology·C S Lieber, L M DeCarli
Dec 1, 1974·Archives of Biochemistry and Biophysics·A I CederbaumE Rubin
Jun 22, 1965·Biochimica Et Biophysica Acta·A Tzagoloff, D H MacLennan
Jun 28, 1968·Biochemical and Biophysical Research Communications·D S Beattie
May 1, 1973·The American Journal of Digestive Diseases·M C OudeaP Oudea
Nov 25, 1970·Biochemical and Biophysical Research Communications·M S Jones, O T Jones
Feb 1, 1968·The American Journal of Medicine·C S Lieber, E Rubin
Dec 1, 1982·European Journal of Pediatrics·F Hadziselimović
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D E Green, M Fry
Jan 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S W FrenchC H Halsted
Dec 12, 1980·Biochimica Et Biophysica Acta·R J Schilling, R C Reitz
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Jan 1, 1962·Archives of Biochemistry and Biophysics·D C WHARTON, D E GRIFFITHS

❮ Previous
Next ❯

Citations

Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S M Bailey, C C Cunningham
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P PerisJ Muñoz-Gómez
Nov 17, 1994·Biochimica Et Biophysica Acta·C P Day, S J Yeaman
Jan 1, 1995·Pharmacology & Therapeutics·B Fromenty, D Pessayre
Mar 1, 1984·Alcohol·C S Lieber
Sep 1, 1993·Baillière's Clinical Gastroenterology·C S Lieber
Apr 14, 2005·Journal of Hepatology·Heinz-Peter Wilhelm SchlemmerHelmut Karl Seitz
Dec 4, 2003·Pharmacology & Therapeutics·Kathleen A Grant, Allyson J Bennett
Jan 5, 2002·Pathologie-biologie·C S Lieber
May 1, 2008·The British Journal of Nutrition·Annabelle GuiraudJoël de Leiris
Jul 1, 1988·The Proceedings of the Nutrition Society·M Davis
Jan 1, 1985·Journal of the American College of Nutrition·M Gascon-Barré
Dec 1, 1991·Journal of the American College of Nutrition·C S Lieber
Apr 1, 1990·Alcoholism, Clinical and Experimental Research·R TsutsumiC S Lieber
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·A WitschiB H Lauterburg
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·A MateosJ Fermoso
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·C S Lieber
Mar 4, 2000·Alcoholism, Clinical and Experimental Research·L J MiC S Lieber
May 20, 1999·Annual Review of Pharmacology and Toxicology·R C Baker, R E Kramer
Feb 13, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kelly K AndringaShannon M Bailey
May 1, 1989·The Journal of Clinical Investigation·C S LieberN Inatomi
Feb 24, 2001·Critical Reviews in Clinical Laboratory Sciences·C S Lieber
Jan 1, 1992·Critical Reviews in Clinical Laboratory Sciences·S W French
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·P Mac MathunaR Williams
Aug 19, 2007·Micron : the International Research and Review Journal for Microscopy·M MartinezF E Martinez
Jun 16, 2007·Life Sciences·Subir Kumar Das, D M Vasudevan
Jun 9, 2015·Biochemical and Biophysical Research Communications·Ying Hui LiEun-Hee Cho
Dec 17, 1987·Biochimica Et Biophysica Acta·P I Spach, C C Cunningham
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S Lieber
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A KasaharaT Kamada
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Galvaõ-TelesD H Van Thiel
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HelzbergE R Gordon
May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Z HussainR S Bhatnagar
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Miyamoto, S W French
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberS Sato
Jun 26, 1999·Gastroenterology·A I Cederbaum
May 1, 1991·Journal of Hepatology·C S Lieber, L M DeCarli
Jan 1, 1995·Gastroenterology·B G Rosser, G J Gores

❮ Previous
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