PMID: 8610515Jan 1, 1995Paper

Biochemical and morphological effects of contrast media on the kidney

Acta Radiologica. Supplementum
M DobrotaH Vik

Abstract

The intravenous use of roentgen contrast media (CM) is associated with a low incidence of renal impairment. This paper considers the intravascular handling and retention of CM in relation to effects on renal function - specifically the ability of the kidney to reabsorb and catabolise low molecular weight proteins. Renal morphology following experimental administration of a high dose of an isotonic dimeric CM (iodixanol at 3 g I/kg) in rats showed numerous, large, protein-containing vacuoles or droplets in the cells of the proximal convoluted tubule. These were fully formed within 3.5 hours. The process of vacuole-formation involving the uptake of CM appears to be analogous to dextran uptake that occurs via fluid phase endocytosis. These vacuoles or CM droplets are abundant for 7 days but then slowly decline over several weeks. The quantitative recovery of (14)C iodixanol (3g I/kg) from the kidneys between 3.5 hours to 7 days after administration was about 1% of the dose, with some 0.2% of the original dose still present at 28 days. Subcellular analysis to determine the site of the radiolabel showed that the (14)C was associated with lysosomal marker enzymes. The CM-induced vacuoles/droplets are most probably giant lysosomes, wh...Continue Reading

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Citations

May 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert E Cronin
Nov 17, 2007·Investigative Radiology·Olaf DöhrHermann Schweinfurth
Jan 3, 2001·American Journal of Physiology. Renal Physiology·K HardiekC Deitrick
Sep 15, 2004·Journal of Toxicology. Clinical Toxicology·Erik Andrew, Knut J Berg
Feb 26, 2011·Clinical and Experimental Pharmacology & Physiology·Mauricio M Sendeski
Aug 25, 2020·Journal of Applied Toxicology : JAT·Paul Baldrick
Sep 27, 2012·Investigative Radiology·Christiane WackRainer Hofmeister
Jun 1, 1997·Investigative Radiology·K J Berg, J A Jakobsen
Dec 30, 2008·Journal of Biochemical and Molecular Toxicology·XunHui XuJianQiang He
Nov 1, 1996·European Journal of Radiology·S K MorcosM Dobrota
Apr 14, 2006·Kidney International. Supplement·R W Katzberg, C Haller

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