PMID: 2861973Mar 1, 1985

Biochemical and physiological effects of S-32-468, a beta-adrenoceptor antagonist with possible oculoselectivity

Current Eye Research
J A Nathanson


S-32-468, a recently synthesized aryloxymethyl beta-adrenoceptor antagonist, was tested for its ability to inhibit activation of isoproterenol-stimulated adenylate cyclase activity in rabbit and human ciliary process, heart and lung. In both species, S-32-468 was a potent inhibitor of ocular beta-adrenoceptors, with a 9-12 fold selectivity over inhibition of beta-adrenoceptors in cardiac tissue. When applied topically, S-32-468 was more effective than timolol in decreasing intraocular pressure in normal albino rabbits.


Jul 1, 1977·British Journal of Pharmacology·J L ImbsC G Wermuth
May 1, 1981·British Journal of Pharmacology·J A Nathanson
Aug 1, 1983·The British Journal of Ophthalmology·A Rushton
Jan 1, 1984·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C J SchmittN N Share
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J A Nathanson
Dec 1, 1982·The British Journal of Ophthalmology·G E Trope, B Clark


Nov 1, 1988·The Journal of Pharmacy and Pharmacology·J A Nathanson, E J Hunnicutt

Related Concepts

Adenylate Cyclase
Adrenergic beta-Antagonists
Ciliary Body
Enzyme Activation
Physiologic Intraocular Pressure

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