PMID: 2505291Jan 1, 1989Paper

Biochemical aspects of tryptophan depletion in primates

Psychopharmacology
S N YoungP Finn

Abstract

We studied the degree of plasma tryptophan depletion produced by giving normal human males different amounts of a tryptophan-free (T-) amino acid mixture. From the results of this and other studies we concluded that the maximum degree of tryptophan depletion can be produced by a 31.5 g mixture of seven essential amino acids. Administration of a T- amino acid mixture to vervet monkeys lowered tryptophan and 5-hydroxyindoleacetic acid in the cerebrospinal fluid. Levels of tyrosine and the catecholamine metabolites were unchanged. These data support the idea that the effects of T- mixture on mental function in humans which have been reported previously are due to a decrease in 5-hydroxytryptamine.

References

Jan 1, 1976·The American Journal of Physiology·W H Oldendorf, J Szabo
Sep 1, 1988·Pharmacology, Biochemistry, and Behavior·S N YoungG H Anderson
Jun 10, 1988·Science·F A KingK G Gould
Dec 1, 1987·Pharmacology, Biochemistry, and Behavior·B ChamberlainS N Young
May 1, 1987·Journal of Studies on Alcohol·R O PihlS Plotnick
Nov 1, 1987·Journal of Studies on Alcohol·C ZacchiaF R Ervin
Jan 1, 1985·Psychopharmacology·S N YoungF R Ervin
Sep 1, 1984·Pharmacological Research Communications·E A MojaG L Gessa

❮ Previous
Next ❯

Citations

Jun 19, 2003·JAMA : the Journal of the American Medical Association·J Douglas BremnerDennis S Charney
May 1, 1995·Psychopharmacology·S C AronsonL H Price
Jul 1, 1996·Psychopharmacology·F G MoellerD R Cherek
Mar 22, 2007·Psychopharmacology·Paolo Fusar-PoliPhilip K McGuire
Mar 23, 2007·Psychopharmacology·Donald M DoughertyAbdulla A-B Badawy
Sep 29, 2007·European Archives of Psychiatry and Clinical Neuroscience·Christine NorraHanns Jürgen Kunert
Apr 1, 1993·Biological Psychiatry·C J McDougleL H Price
Jul 15, 1995·Biological Psychiatry·A W GoddardL H Price
Dec 1, 1994·Biological Psychiatry·A W GoddardL H Price
Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·F V Abbott, S N Young
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·L H PriceG R Heninger
Mar 12, 1998·Biological Psychiatry·F CassidyB J Carroll
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Mary PeruginiVerner Knott
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Michael A TaffeLisa H Gold
Mar 29, 1997·Lancet·K A SmithP J Cowen
Jun 23, 2000·Behavioural Brain Research·F V Abbott, K G Hellemans
Jan 1, 1997·Clinical Psychology Review·M E BermanE F Coccaro
Mar 26, 2002·Biological Psychology·Stefan DebenerBurkhard Brocke
Jun 1, 1997·Nutrition·L Christensen
Nov 12, 2002·Respiratory Physiology & Neurobiology·Lukasz StruzikMartin A Katzman
Jun 26, 2009·Social Cognitive and Affective Neuroscience·Arwen B LongMichael L Platt
Jul 6, 2005·The Australian and New Zealand Journal of Psychiatry·Sean D HoodDavid J Nutt
May 8, 2000·Alcoholism, Clinical and Experimental Research·M LeytonC Benkelfat
Apr 1, 2008·Acta Neuropsychiatrica·Janet MacePeter Gallagher
Feb 23, 2013·Journal of Psychiatry & Neuroscience : JPN·Simon N Young
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S NishizawaM Diksic
May 28, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Ashraf SalmanipourRahman Hosseinzadeh
Jul 29, 2003·Psychosomatic Medicine·Sascha RussoJakob Korf
Jul 30, 2014·Brain : a Journal of Neurology·Eileen DalyDeclan G M Murphy
Sep 26, 2013·Journal of Neural Transmission·Cristina L SánchezFlorian D Zepf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.