Biochemical changes in the cervical mucus after application of laminaria tent

Acta Obstetricia Et Gynecologica Scandinavica
E El MaradnyT Terao

Abstract

This research was aimed to study the biochemical changes in cervical mucus after application of laminaria tent. Cervical mucus was collected before and after insertion of laminaria tent from 20 normal pregnant women in the first and second trimesters. Interleukin-1 beta, IL-8, collagenase activity, elastase activity, PGE2 and PGF2 alpha were measured in the collected samples. Laminaria tent was also inserted in one vaginal cervix of five non-pregnant rabbits and the clinical and histological changes were compared with five non-treated rabbits. Collagen contents were assessed histologically and Leukocyte number was counted. IL-1 beta and IL-8 and elastase activity were significantly increased after insertion of laminaria (p<0.0001 and 0.001 respectively). Collagenase activity was not significantly changed. Whereas concentration of PGE2 and PGF2 alpha in the mucus were markedly increased (p<0.0001 and 0.001 respectively). Collagen contents were significantly decreased in laminaria and opposite side cervices (p<0.0001). No significant changes in leukocyte count could be observed in treated and non treated cervices. Insertion of laminaria leads to increase concentration of IL-1 beta, IL-8, PGE2, PGF2 alpha and elastase activity. Me...Continue Reading

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Citations

Jul 2, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y P ChungT M Ko
Jul 14, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F GhezziP Bolis
Feb 3, 2007·Taiwanese Journal of Obstetrics & Gynecology·Shin-Yu LinChien-Nan Lee
Sep 17, 2008·Reproductive Health Matters·Patricia A Lohr
Sep 6, 2015·Seminars in Perinatology·Danielle DuriePhillip Zegelbone
Jul 5, 2003·Placenta·J A KeelanM D Mitchell
Feb 15, 2019·The Journal of Obstetrics and Gynaecology Research·Misooja LeeTadashi Kimura

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