PMID: 488765Aug 1, 1979Paper

Biochemical changes in the jejunal mucosa of dogs with naturally occurring exocrine pancreatic insufficiency

Gut
R M BattT J Peters

Abstract

The roles of extracellular and intracellular mechanisms in the degradation of brush border proteins have been investigated by studying the small intestinal mucosa of dogs with naturally occurring exocrine pancreatic insufficiency. Peroral jejunal biopsies were homogenised and the organelles separated by isopycnic centrifugation on continuous sucrose density gradients. The distributions of marker enzymes for the principal subcellular organelles were determined in the gradients and related to the specific activities in the homogenates. There were increased activities of the brush border carbohydrases zinc-resistant alpha-glucosidase, maltase and sucrase in the pancreatic insufficient animals, but no change in lactase activity. The activity of gamma-glutamyl transferase was also higher in the affected group; the activities of two other brush border enzymes, alkaline phosphatase and leucyl-beta-naphthylamidase, however, were unaltered. These findings with an increase in the modal density of the brush border from 1.20 to 1.22 are consistent with an enhanced glycoprotein content of the microvillus membrane. There were also rises in the activities of lysosomal enzymes. N-Acetyl-beta-glucosaminidase activity was increased in the solubl...Continue Reading

References

Jun 1, 1976·Clinical Science and Molecular Medicine·R M Batt, T J Peters
Mar 1, 1979·The Journal of Small Animal Practice·R M BattT J Peters
Jan 1, 1977·Annual Review of Biochemistry·S C SilversteinZ A Cohn
May 1, 1979·The Journal of Small Animal Practice·R M Batt
Nov 1, 1978·Clinical Science and Molecular Medicine·R M BattT J Peters
Apr 1, 1976·Biochemical Medicine·T J PetersJ Tilleray
Aug 5, 1975·Biochimica Et Biophysica Acta·D H Alpers, F J Tedesco
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J D BaxterG M Tomkins
Jan 1, 1973·Metabolism: Clinical and Experimental·T D Gelehrter
Feb 1, 1973·Analytical Biochemistry·G R Schacterle, R L Pollack
May 1, 1974·The American Journal of Digestive Diseases·C Arvanitakis, W A Olsen
Jan 1, 1966·Annual Review of Physiology·C De Duve, R Wattiaux
Jul 1, 1971·Journal of Comparative Pathology·F W HillD E Kidder

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Citations

Jan 1, 1982·Archives of Dermatological Research·S Gutschmidt, D Tsambaos
Oct 1, 1982·Digestive Diseases and Sciences·F Senegas-BalasA Ribet
May 1, 1979·The Journal of Small Animal Practice·R M Batt
Nov 1, 1991·Journal of Veterinary Internal Medicine·H C RutgersJ E Riley
Mar 1, 1989·Scandinavian Journal of Gastroenterology·K VetvikO J Halvorsen
Oct 1, 1980·The Journal of Small Animal Practice·R M Batt
Sep 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·R M JacobsV E Valli

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