Biochemical characterization of breast tumors by in vivo and in vitro magnetic resonance spectroscopy (MRS)

Biophysics Reviews
Uma Sharma, Naranamangalam R Jagannathan

Abstract

Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have evolved as sensitive tools for anatomic and metabolic evaluation of breast cancer. In vivo MRS studies have documented the presence of choline containing compounds (tCho) as a reliable biochemical marker of malignancy and also useful for monitoring the tumor response to therapy. Recent studies on the absolute quantification of tCho are expected to provide cut-off values for discrimination of various breast pathologies. Addition of MRS investigation was also reported to increase the specificity of MRI. Further, ex vivo and in vitro MRS studies of intact tissues and tissue extracts provided several metabolites that were not be detected in vivo and provided insight into underlying biochemistry of the disease processes. In this review, we present briefly the role of various (1)H MRS methods used in breast cancer research and their potential in relation to diagnosis, monitoring of therapeutic response and metabolism.

References

Dec 1, 1988·Radiology·P E SijensP R Luyten
Oct 14, 1998·Radiology·J R RoebuckR E Lenkinski
Aug 10, 1999·Journal of Magnetic Resonance Imaging : JMRI·K A KvistadO Haraldseth
Oct 2, 2001·CA: a Cancer Journal for Clinicians·R T GreenleeM Thun
Aug 22, 2002·Journal of the National Cancer Institute·Rachel Katz-BrullRobert E Lenkinski
Aug 31, 2002·NMR in Biomedicine·Beathe SitterIngrid S Gribbestad
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick J BolanMichael Garwood
Jun 19, 2004·Cancer Research·Kristine GlundeZaver M Bhujwalla
Sep 8, 2004·European Radiology·Peter StanwellCarolyn Mountford
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick J BolanMichael Garwood
Jan 15, 2005·Technology in Cancer Research & Treatment·M Albert ThomasNanette DeBruhl
Oct 18, 2005·NMR in Biomedicine·Beathe SitterIngrid S Gribbestad
Dec 27, 2005·Magnetic Resonance Imaging·Vuthaluru SeenuNaranamangalam R Jagannathan
Oct 20, 2006·Breast Cancer Research and Treatment·Gary M TseWei-Tse Yang
Oct 25, 2006·Breast Cancer Research and Treatment·Tone F BathenSteinar Lundgren
Mar 14, 2008·La Radiologia medica·F SardanelliF Podo
Apr 22, 2008·Journal of Magnetic Resonance Imaging : JMRI·Hyeon-Man BaekMin-Ying Su

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Citations

May 28, 2020·Biophysics Reviews·Naranamangalam R Jagannathan

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