Biochemical diagnosis of liver disease

Indian Journal of Clinical Biochemistry : IJCB
P L Wolf


It is important that clinicians and laboratorians, including clinical chemists and pathologists, recognize and understand the clinical significance of abnormal liver function tests. The liver regulates many important metabolic functions. Hepatic injury is associated with distortion of these metabolic functions. Hepatic disease can be evaluated and diagnosed by determining serum concentrations of a number of serum analytes. Many serum analytes exist to assist in the biochemical diagnosis of liver disease. The focus of this paper is on the analytes which are associated with hepatic necrosis, cholestasis, defects in excretion and end stage hepatic disease which results in decreased synthetic function. The abnormalities of these serum analytes will be correlated with the important types of liver disease.


Oct 16, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·T HadaY Yamamura
Aug 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·L M Killingsworth
Jan 1, 1975·Annual Review of Biochemistry·H Danielsson, J Sjövall
Aug 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J N BradbeerJ Reeve
Oct 1, 1990·Clinical Biochemistry·E Schmidt, F W Schmidt
Jul 1, 1990·Journal of Gastroenterology and Hepatology·N Tygstrup
Jan 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·C S Hill, R L Wolfert
Dec 1, 1988·Digestive Diseases and Sciences·J J Reichling, M M Kaplan
Mar 3, 1989·JAMA : the Journal of the American Medical Association·P A SiraganianR W Miller
Oct 2, 1969·The New England Journal of Medicine·L L StolbachW H Fishman
Jun 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·S B Rosalki, D Rau
Jul 24, 1969·The New England Journal of Medicine·P WolfJ Swanson
May 14, 1966·British Medical Journal·D J BirkettS Posen
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B NalpasP Berthelot
Aug 1, 1982·British Journal of Obstetrics and Gynaecology·N J Wald, H S Cuckle
Dec 1, 1983·Archives of Internal Medicine·J K Corless, H M Middleton
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·J A Lott, P W Landesman
Feb 1, 1984·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·M PanteghiniR Bonora
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·P L Wolf
Aug 1, 1980·Postgraduate Medical Journal·K P Ball
Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·V O Van Hoof, M E De Broe
Oct 9, 1996·JAMA : the Journal of the American Medical Association·K M DoyleM Laposata


Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·D S Raghavendra, S B Rao
Nov 28, 2007·Archives of Pharmacal Research·Yong Pil HwangHye Gwang Jeong
Apr 17, 2010·Cell Biology and Toxicology·Ethel Antunes WilhelmCristina Wayne Nogueira
Sep 17, 2013·Biological Trace Element Research·Akram EidiShahabeddin Safi
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Feroz Ahmad, Nahida Tabassum
Aug 25, 2005·Journal of Medicinal Food·M ShahjahanC S Shyamala Devi
Mar 26, 2008·Journal of Medicinal Food·Caroline DaniJoão A P Henriques
Jun 16, 2012·Pharmacognosy Magazine·Bhaskarmurthy Deepak HiraganahalliAmit Agarwal
Jan 18, 2013·Journal of Ayurveda and Integrative Medicine·Krishna Chaitanya D AnanthaReddy A Manohar
Apr 8, 2014·International Journal of Hepatology·Zahra HesamiAkbar Vahdati
Nov 7, 2012·Drug and Chemical Toxicology·Sandesh SanchetiSung-Yum Seo
Apr 12, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Madhusudanarao VudaPrakash Mungli
Sep 12, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hussain ZeashanChandana Venkateswara Rao
Mar 30, 2007·Journal of Ethnopharmacology·Didem Deliorman OrhanFatma Ergun
Aug 25, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Rhitajit SarkarNripendranath Mandal
Oct 11, 2005·Journal of Ethnopharmacology·Guntupalli M Mohana RaoAnnie Shirwaikar
Sep 1, 2012·Toxicological Research·Sang Wha LeeWol-Soon Jo
Jan 23, 2015·Pharmaceutical Biology·Nikhil Baban GhateNripendranath Mandal
Sep 18, 2012·Pharmaceutical Biology·R RajamuruganC Thirunavukkarasu
Feb 27, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sreena Raj, K M Gothandam
Feb 2, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Julie CarillonJean-Max Rouanet
Mar 5, 2015·Saudi Journal of Biological Sciences·Atef M Al-Attar, Nessreen A Shawush
Oct 14, 2016·Frontiers in Pharmacology·Reham H MekkyEssam Abdel-Sattar
Jul 14, 2010·The American Journal of Chinese Medicine·Jen-Chieh TsaiChao-Ying Lee
Feb 4, 2010·The American Journal of Chinese Medicine·Saleh Alqasoumi
Apr 20, 2017·Journal of Biochemical and Molecular Toxicology·Amany M GadEbtehal Mohammad Fikry
Feb 20, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·P Moshaie-NezhadA Khamesipour
Aug 12, 2009·Journal of Biological Physics·Maurizio De PittàEshel Ben-Jacob
Oct 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weide MaLi Tang
Mar 1, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Sudip PaulMd Ibrahim Khalil
Mar 6, 2017·BMC Complementary and Alternative Medicine·Jen-Chieh TsaiWen-Huang Peng
Jul 31, 2019·Journal of Cancer Prevention·Da-Young Lee, Eun-Hee Kim
Feb 3, 2017·BMC Infectious Diseases·Lilishia GounderMahomed-Yunus S Moosa
May 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhaowen DingWei Wei
Dec 4, 2020·Bioorganic & Medicinal Chemistry·Guoqing SuiWenming Zhou
Jun 30, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Oleg SlivcaTimothy L Pruett
Feb 20, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ioannis A ZiogasMartin I Montenovo
Mar 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Md Mizanur RahmanMd Ashraful Alam

Related Concepts

Kidney Failure, Chronic
Liver Diseases
Hepatic Necrosis
Injury of Hepatic Artery
Excretory Function
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